Broad and Potent Neutralizing Antibodies Are Elicited in Vaccinated Individuals Following Delta/BA.1 Breakthrough Infection
Source : https://journals.asm.org/doi/10.1128/mbio.01206-23
With the emergence of SARS-CoV-2 viral variants, there has been an increase in infections in vaccinated individuals. Here, we isolated monoclonal antibodies (mAbs) from individuals experiencing a breakthrough infection (Delta...
Overall, despite broad neutralization of BA.1, BA.2, and BA.4, the convergent RBD mutations in BA.2.75.2, XBB/XBB.1.5, and BQ.1.1 lead to extensive immune evasion to mAbs generated following Delta and BA.1 BTI. Several potent cross-neutralizing mAbs were identified and additional structural studies would provide important insights into how...
Accelerated and Intensified Manufacturing of an Adenovirus-Vectored Vaccine to Enable Rapid Outbreak Response
Source : https://pubmed.ncbi.nlm.nih.gov/37747758/
The Coalition for Epidemic Preparedness Innovations' "100-day moonshot" aspires to launch a new vaccine within 100 days of pathogen identification, followed by large-scale vaccine availability within the "second hundred days."...
This accelerated manufacturing process, along with other advantages such as thermal stability, supports the ongoing value of adenovirus-vectored vaccines as a rapidly adaptable and deployable platform for emergency response.
Design, synthesis, antiviral activities of ferulic acid derivatives
Source : https://www.frontiersin.org/articles/10.3389/fphar.2023.1133655/full
A series of novel ferulic acid derivatives were designed and synthesized, and the twenty-one compounds were evaluated for their antiviral activities against Respiratory syncytial virus (RSV), herpes simplex virus type...
Relevance: A series of novel ferulic acid derivatives were designed and synthesized, and the twenty-one compounds were evaluated for their antiviral activities against Respiratory syncytial virus (RSV), herpes simplex virus type 1 (HSV-1), and enterovirus type 71 (EV71).
Factors Associated With Non-Vaccination for Influenza Among Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37717847/
Possible residual confounding CONCLUSION: Among adults with CKD receiving nephrology care, younger adults, Black individuals, and those with adverse social determinants of health were more likely to have the influenza...
Rationale & Objective: Vaccination for influenza is strongly recommended for people with chronic kidney disease (CKD) due to their immunocompromised state. Identifying risk factors for not receiving an influenza vaccine (“non-vaccination”) could inform strategies for improving vaccine uptake in this high-risk population.
Significance of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Preoperative Nutritional Index as Predictors of Morbidity in Patients Who Underwent Liver Resection for Alveolar Echinococcosis
Aim: We aimed to evaluate the significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and preoperative nutritional index (PNI) as predictors of morbidity in patients who underwent liver resection for...
Conclusion: From the results of the present study, it was found that preoperative parameters did not affect morbidity, while increased postoperative NLR levels and decreased lymphocyte rates increased morbidity.