Breakthrough SARS-CoV-2 infections in immune mediated disease patients undergoing B cell depleting therapy: A retrospective cohort analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35791921/
doi: 10.1002/art.42287. Online ahead of print. 1 Department of Rheumatic and Immunologic Diseases, Cleveland Clinic. 2 Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic. 3 Department of Dermatology,...
Conclusions: IMIDs patients on BCDT regardless of vaccine status appear vulnerable to infection with SARS-CoV-2 and are frequently associated with severe outcomes. Outpatient use of anti-SARS-CoV-2 monoclonal antibody therapy appeared to be associated with enhanced clinical outcomes.
Association of periodic fasting with lower severity of COVID-19 outcomes in the SARS-CoV-2 prevaccine era: an observational cohort from the INSPIRE registry
Source : https://nutrition.bmj.com/content/early/2022/06/30/bmjnph-2022-000462
Objectives Intermittent fasting boosts some host defence mechanisms while modulating the inflammatory response. Lower-frequency fasting is associated with greater survival and lower risk from COVID-19-related comorbidities. This study evaluated associations...
Conclusions: Routine periodic fasting was associated with a lower risk of hospitalisation or mortality in patients with COVID-19. Fasting may be a complementary therapy to vaccination that could provide immune support and hyperinflammation control during and beyond the pandemic.
Poxviruses package viral redox proteins in lateral bodies and modulate the host oxidative response
Source : https://doi.org/10.1371/journal.ppat.1010614
Author summary Vaccinia virus is the prototype member of the Poxviridae family, whose members include monkeypox and variola virus, the causative agent of smallpox. All poxvirus particles, including vaccinia, are...
Using targeted repression and/or deletion viruses we found that deletion of individual LB-redox proteins was insufficient for host redox modulation suggesting there may be functional redundancy. In addition to defining the spatial proteotype of VACV LBs, these findings implicate poxvirus redox proteins as potential modulators of host oxidative...
Transient Global Amnesia Related to the Third Coronavirus Disease-19 (COVID-19) Vaccination
We present a case report of transient global amnesia (TGA) after vaccinating the third dose of coronavirus disease-19 (COVID-19). A 65-year-old Japanese woman presented with TGA after her third vaccination,...
Conclusions: We experienced the case with TGA after the third COVID-19 vaccination. A 65-year-old Japanese woman showed TGA after her third vaccination, which spontaneously resolved. This article aims to facilitate the clinicians’ understanding that TGA could occur after vaccination in the COVID-19 global outbreak. We should be careful of...
Interpretation: Vaccination against COVID-19 in children aged 5–11 years in Italy showed a lower effectiveness in preventing SARS-CoV-2 infection and severe COVID-19 than in individuals aged 12 years and older. Effectiveness against infection appears to decrease after completion of the current primary vaccination cycle.