Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age | NEJM
Source : https://www.nejm.org/doi/full/10.1056/NEJMoa2203315
Original Article List of authors. C. Buddy Creech, M.D., M.P.H., Evan Anderson, M.D., Vladimir Berthaud, M.D., M.P.H., Inci Yildirim, M.D., Ph.D., Andrew M. Atz, M.D., Ivan Melendez Baez, M.D., Daniel...
CONCLUSIONS: Two 50-μg doses of the mRNA-1273 vaccine were found to be safe and effective in inducing immune responses and preventing Covid-19 in children 6 to 11 years of age; these responses were noninferior to those in young adults.
Pioneering study identifies global dynamics of Antibiotic Resistance
Source : https://www.exeter.ac.uk/news/homepage/title_913713_en.html
Antibiotic resistance is recognised as being one of the most significant threats to global health Scientists have used ideas from artificial intelligence to identify patterns of antibiotic resistance around the...
We sought data anomalies whereby MICs could shift for methodological and not clinical or microbiological reasons and found artefacts in over 100 pathogen-antibiotic pairs. Using an information-optimal clustering methodology to classify pathogens into low and high antibiotic susceptibilities, we used ATLAS to predict changes in resistance....
SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5 - Nature Communications
Source : https://www.nature.com/articles/s41467-022-30609-9
SERINC5, is a cellular multipass transmembrane protein involved in sphingolipid and phosphatydilserine biogenesis and a known retroviral restriction factor. Here, Timilsina et al. show that SERINC5 is a host restriction...
Here, we show SERINC5 inhibits SARS-CoV-2 entry by blocking virus-cell fusion, and SARS-CoV-2 ORF7a counteracts the antiviral effect of SERINC5 by blocking the incorporation of over expressed SERINC5 in budding virions.
Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19 - Genome Medicine
Background Natural killer (NK) cells are innate lymphoid cells that mediate antitumour and antiviral responses. However, very little is known about how ageing influences human NK cells, especially at the...
Conclusions: We identified a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19. Our results identify memory-like NK2.1 cells as a potential target for developing immunotherapies for infectious diseases and for addressing age-related dysfunctions of the immune system.
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice
Source : https://doi.org/10.1371/journal.ppat.1010498
Author summary Antivirals targeting SARS-CoV-2 are sorely needed. In this study, we screened a library of approximately 2000 drug compounds that have been used or are still used in the...
Notably, the peak concentration of clofoctol that can be achieved in human lungs is more than 20 times higher than its IC50 measured against SARS-CoV-2 in human pulmonary cells. This compound inhibits SARS-CoV-2 at a post-entry step. Lastly, therapeutic treatment of human ACE2 receptor transgenic mice decreased viral load, reduced inflammatory...