Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England
Source : https://doi.org/10.1371/journal.pmed.1003926
William N. Whiteley, Samantha Ip, Jennifer A. Cooper, Thomas Bolton, Spencer Keene, Venexia Walker, Rachel Denholm, Ashley Akbari, Efosa Omigie, Sam Hollings has COMPANION First dose ChAdOx1 and BNT162b2 COVID-19...
Conclusions: In this study, we observed increases in rates of ICVT and thrombocytopenia after ChAdOx1-S vaccination in adults aged
Using dipstick urinalysis to predict development of acute kidney injury in patients with COVID-19 - BMC Nephrology
Source : https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-022-02677-y
Background Acute kidney injury (AKI) is a common complication in patients hospitalized with COVID-19 and may require renal replacement therapy (RRT). Dipstick urinalysis is frequently obtained, but data regarding the...
Conclusions: Proteinuria and hematuria values on dipstick urinalysis can be utilized to predict AKI and RRT in hospitalized patients with COVID-19. We derived formulas using these two readily available values to help prognosticate kidney outcomes in these patients. Furthermore, the incorporation of CKD or baseline creatinine increases the...
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection - Nature Immunology
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3-11 years)...
Importantly, children retained antibody and cellular responses 6 months after infection, whereas relative waning occurred in adults. Spike-specific responses were also broadly stable beyond 12 months. Therefore, children generate robust, cross-reactive and sustained immune responses to SARS-CoV-2 with focused specificity for the spike...
COVID-19 genetic risk variant protects against HIV
Source : https://medicalxpress.com/news/2022-02-covid-genetic-variant-hiv.html
The genetic variants we are born with can increase or decrease our risk of falling seriously ill with COVID-19. The major genetic risk variant for severe COVID-19, one we inherited...
"This shows how a genetic variant can be both good and bad news: Bad news if a person contracts COVID-19, good news because it offers protection against getting infected with HIV," says Zeberg.
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2
Omicron, delta, and prototype SARS-CoV-2 RBDs show similar binding strength to hACE2 * The complexes of SARS-CoV-2-RBD with hACE2 for omicron and delta variants were resolved * The roles of...
Highlights
- Omicron, delta, and prototype SARS-CoV-2 RBDs show similar binding strength to hACE2
- The complexes of SARS-CoV-2-RBD with hACE2 for omicron and delta variants were resolved
- The roles of key residues in the omicron RBD for receptor recognition were identified