Impact of newly diagnosed diabetes on COVID‐19 severity and hyperglycemia
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/jdi.13754
Corresponding Author Ryotaro Bouchi Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine, Toyama 1-21-1, Shinjuku-ku, Tokyo, 162-8655 Japan Diabetes and Metabolism Information Center, Research Institute,...
Conclusions: Our study suggests that the proportion of COVID-19 patients who are newly diagnosed with diabetes is high, and they have an increased risk of developing severe disease than those with pre-existing diabetes. It may be advisable that at the point of COVID-19 diagnosis, blood glucose and HbA1c levels be assessed in all patients.
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells
Source : https://www.pnas.org/content/119/6/e2113874119
Human angiotensin-converting enzyme 2 (ACE2) is the most widely known entry receptor for SARS-CoV-2. The possible involvement of other cellular components in viral entry mechanisms remains unknown. Vimentin is expressed...
Significance: Human angiotensin-converting enzyme 2 (ACE2) is the most widely known entry receptor for SARS-CoV-2. The possible involvement of other cellular components in viral entry mechanisms remains unknown. Vimentin is expressed in human endothelial cells, binds to SARS-CoV-2-spike, and expedites SARS-CoV-2 entry. Treatment of lung...
Achromobacter xylosoxidans Purulent Bronchitis in a Previously Healthy Child: An Unexpected Consequence of COVID-19 Infection
Achromobacter xylosoxidans is an aerobic, Gram-negative rod with a broad intrinsic and acquired antimicrobial resistance, usually isolated in patients with cystic fibrosis (CF), immunodeficiencies, or those undergoing invasive procedures. We...
Since the patient had positive serological testing for coronavirus disease 2019 (COVID-19), we concluded that it was the initial viral infection, although of a mild clinical course, the one that created favorable conditions for proliferation and further inflammation caused by A. xylosoxidans.
Highlights
- 44% of hospitalized children and SARS-CoV-2 condition had neurologic manifestations
- More children with MIS-C had neurologic manifestation vs. acute SARS-CoV-2
- Headache and encephalopathy were the most common neurologic manifestations
- Older children and those with preexisting conditions were at higher risk
Cytokine profiles in the detection of severe lung involvement in hospitalized patients with COVID-19: The IL-8/IL-32 axis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35063722/
Coronavirus disease 2019 (COVID-19) is an infectious respiratory disorder caused by a new coronavirus called SARS-CoV-2. The pathophysiology of severe COVID-19 is associated with a "cytokine storm". IL-32 is a...
The cytokines that best distinguished controls from COVID-19 patients were IL-8 and IL-32, while IL-6 resulted the better variables for discriminate severe group. The best model performance for severe group was obtained by the combination of IL-32, IL-6, IFN-γ, and CRP serum concentration showing an AUC = 0.83. A cut off of 15 pg/ml of IL-6...