ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
Source : https://www.science.org/doi/10.1126/sciadv.abl8213
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These data confirm that PF4 is capable of forming stable complexes with clinically relevant adenoviruses, an important step in unraveling the mechanisms underlying TTS.
The primary outcome was the reciprocal of neutralizing antibody titers against a live Wuhan strain (eAppendix in the Supplement). Secondary outcomes included IgG antibodies to the spike protein and receptor-binding domain (RBD) using a multiplex assay (V-PLEX COVID-19 Coronavirus Panel 2 [IgG] Kit, Meso Scale Diagnostics); antibodies to spike...
Conclusions: Most cases of suspected COVID-19 vaccine myocarditis occurring in persons
Collectively, these results support the notion that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that fluvastatin has a moderate beneficial effect on SARS-CoV-2 infection of human lung cells.
In summary, the developed vaccine can elicit a multifaceted immune response and induce robust viral clearance in the URT, which make it a potential vaccine for preventing disease and infection of SARS-CoV-2.