Meaning: Vaccination with an mRNA COVID-19 vaccine was significantly less likely among patients with COVID-19 hospitalization and with disease progression, consistent with risk reduction among vaccine breakthrough infections

Conclusions and relevance: In this cohort study, in silico analysis of drug-associated gene expression signatures identified potential ACE2-lowering antineoplastic compounds, including mTOR/PI3K inhibitors and antimetabolites. Patients who received these compounds exhibited statistically significantly lower rates of SARS-CoV-2 infection...

Conclusion: Lymphocytes and monocyte ratios inpatient with COVID-19 infection can be used as predictors for the severity of infection. Increased leukocyte count resulted in increases in platelets inpatient with COVID-19.

Highlights

• Prenatal SARS-CoV-2 infection triggers NF-κB-dependent immune activation
  
• Pregnant women with severe COVID-19 show antiviral IFN-λ signaling
  
• SARS-CoV-2 infection re-shapes maternal immunity at delivery
  
• COVID-19-exposed infants exhibit altered neonatal immunity at birth
  

In conclusion, against the current backdrop of the dominant D variant that could be further complicated by co-infection synergy with new variants, the growing list of viruses susceptible to TG, a promising host-centric antiviral, now includes a spectrum of contemporary SARS-CoV-2 viruses.