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56yr

Fun Fact! Statin-associated liver injury (SILI) is rare, with true liver damage seen in just 1 in 1,000 to 1 in 10,000 patients. Though 2.8–3.1% show elevated liver enzymes, most cases are mild and resolve after stopping treatment. Interestingly, statins may offer protection against chronic liver diseases like cirrhosis.

Could statins play a dual role in both managing cholesterol and protecting liver health?

NCCN Guidelines

Could statins play a dual role in both managing cholesterol and protecting liver health?

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3mo
Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis - PubMed

Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39183456/

Aim: This meta-analysis investigates the association between testosterone replacement therapy [TRT] and carotid artery atherosclerosis. Methods: 3 databases were searched for studies up to June 2023 per the PRISMA guidelines....

Testosterone therapy shows no association with carotid atherosclerosis or lipid/inflammatory markers, though it raises testosterone levels, suggesting safe use in hypogonadal men without increasing CIMT risk.

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3mo
case study

Patient Background: A 79-year-old woman presented with persistent hypophosphatemia (serum phosphorus 0.8 mg/dL) and multiple stress fractures involving the ribs, spine, and pelvis, consistent with osteomalacia. Her medical history included type 2 diabetes mellitus, hypertension, obesity, osteoarthritis, and anxiety disorder.

Assessment and Diagnosis: Initial evaluation revealed severe hypophosphatemia (0.8 mg/dL; NR: 2.5–4.5 mg/dL), elevated parathyroid hormone (PTH, 169 pg/mL; NR: 10–65 pg/mL), and normal serum calcium levels. Despite vitamin D supplementation, hypophosphatemia persisted (1.7 mg/dL in 2023), and hypercalcemia developed later (10.9 mg/dL; NR: 8.5–10.2 mg/dL). Renal studies showed phosphate wasting (tubular reabsorption of phosphate [TRP] 56.2%) and elevated fibroblast growth factor 23 (FGF-23, 1694 kRU/L). In 2024, ^18F-fluorocholine PET-CT imaging identified two right parathyroid adenomas, confirming a diagnosis of primary hyperparathyroidism (PHPT).

  1. How can chronic hypophosphatemia signal early-stage PHPT?
  2. Why is postoperative monitoring vital in PHPT care?
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3mo
Does Genotype Affect the Efficacy of PCSK9 Inhibitors in the Treatment of Familial Hypercholesterolemia? - PubMed

Does Genotype Affect the Efficacy of PCSK9 Inhibitors in the Treatment of Familial Hypercholesterolemia? - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37610687/

Currently, available evidence consistently demonstrates and is in good agreement that, in general, the LDL-C-lowering effect of PCSK9 inhibitors is similar across genotypes, except for compound heterozygous and homozygous familial...

Genetic background slightly affects PCSK9 inhibitors’ LDL-C lowering in familial hypercholesterolemia, with reduced response in compound heterozygous and homozygous cases; clinical factors remain key for management.

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3mo
Effect of fatty acid profiles in varying recipes of ready-to-use therapeutic foods on neurodevelopmental and clinical outcomes of children (6-59 months) with severe wasting: a systematic review - PubMed

Effect of fatty acid profiles in varying recipes of ready-to-use therapeutic foods on neurodevelopmental and clinical outcomes of children (6-59 months) with severe wasting: a systematic review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38134960/

PROSPERO registration no. CRD42022303694.

This systematic review found that ready-to-use therapeutic foods (RUTFs) with improved omega-3 fatty acid profiles and lower n-6:n-3 ratios enhanced neurodevelopmental scores, DHA status, and survival in children with severe acute malnutrition.

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