Cardiometabolic and Renal Phenotypes and Transitions in the United States Population
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615595/
Cardiovascular and renal conditions have both shared and distinct determinants. In this study, we applied unsupervised clustering to multiple rounds of the National Health and Nutrition Examination Survey from 1988...
The cardiometabolic and renal traits of the US population have shifted from phenotypes with high blood pressure and cholesterol toward poor kidney function, hyperglycemia, and severe obesity.
Share
Ceramides Improve Cardiovascular Risk Prediction Beyond Low-Density Lipoprotein Cholesterol
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826640/
Low-density lipoprotein cholesterol (LDL-C) is the best documented cardiovascular risk predictor and at the same time serves as a target for lipid-lowering therapy. However, the power of LDL-C to predict...
Ceramides- and phosphatidylcholine-based predictors rather than LDL-C may be used for a more accurate cardiovascular risk prediction in patients at high risk.
Share
Presence of familial hypercholesterolemia variants was associated with a 2-fold higher risk of coronary heart disease, even when LDL-C levels were moderately elevated.
Share
Effect of Supplementation With Probiotics or Synbiotics on Cardiovascular Risk Factors in Patients With Metabolic Syndrome: a Systematic Review and Meta-Analysis of Randomized Clinical Trials
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801034/
The effectiveness of probiotics or synbiotics in adults with metabolic syndromes (MetS) remains controversial, this meta-analysis will further analyze the effects of probiotics or synbiotics on cardiovascular factors in adults...
Supplementation with probiotics or synbiotics can reduce BMI, LDL-C, and fasting blood glucose in patients with metabolic syndrome, but the findings did not demonstrate a favorable effect on reducing systolic blood pressure.
Share
Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801839/
Familial hypercholesterolemia is a monogenic disorder that leads to premature atherosclerosis as a result of lifelong exposure to elevated low-density lipoprotein cholesterol (LDL-C). Both genetic traits and lifestyle factors can...
Patients with a family history of hypercholesterolemia and significantly elevated LDL-C without other major comorbidities can be evaluated with genetics to further elucidate their overall CV risk profile and alter management.
Share