Highlights: "•Recent major clinical trials for lipid lowering therapy emphasize ‘lower the better’ concept in low density lipoprotein.•Optimal target low density lipoprotein cholesterol level is not fully investigated in Korean acute myocardial infarction•Target low density lipoprotein cholesterol levels of
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Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
Source : https://doi.org/10.1155/2021/5881321
The present study aimed to explore the effects of shikonin (SKN) on the damage of human venous endothelial cells (HUVECs) induced by ox-LDL and the underlying molecular mechanism. The HUVECs...
The level of TNF-α, IL-1β, IL-6, vascular cell adhesion molecule-1 (VCAM1), intercellular adhesion molecule-1 (ICAM1), and E-selectin (E-sel) was increased, ROS levels increased, and superoxide dismutase (SOD) level decreased. Moreover, the protein levels of p-AMPK, Nrf2, and HO-1 were decreased. Compared to the ox-LDL group, SKN treatment...
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Conclusion: "Our data show increased discordance between ApoB and LDL-C is associated with cardiometabolic, clinical and dietary abnormalities and that body fat percentage is causal of elevated ApoB."
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This chapter shows the potential of probiotic strains protecting against CVD based on clinical trials, systematic reviews, and meta-analyses. The suggested mechanisms for the hypolipidemic effects of the probiotic are also discussed.
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Dill supplementation significantly improved LDL-C, TG, and TC levels but not HDL-C. Further high quality controlled clinical trials on human is needed for more accurate and confirm conclusion.
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