Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and "Missing" Heritability
Source : https://www.mdpi.com/2227-9059/9/11/1728
Changes in plasma low-density lipoprotein cholesterol (LDL-c) levels relate to a high risk of developing some common and complex diseases. LDL-c, as a quantitative trait, is multifactorial and depends on...
This paper discusses other possibilities for unexplained dyslipidemias associated with LDL-c, such as mosaicism, maternal effect, and induced epigenetic changes. Future studies should consider gene–gene and gene–environment interactions and the development of integrated information about disease-driving networks, including phenotypes,...
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Lipid Management Connect4yrKey Points • Source: Biomedicines • Conclusion/Relevance: “This paper discusses other possibilities for unexplained dyslipidemias associated with LDL-c, such as mosaicism, maternal effect, and induced epigenetic changes. Future studies should consider gene–gene and gene–environment Show More
Machine Learning Estimation of Low-Density Lipoprotein Cholesterol in Women with and without HIV - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34813572/
doi: 10.1097/QAI.0000000000002869. Online ahead of print. 1 Department of Internal Medicine, University Hospitals/Case Western Reserve University, Cleveland, OH Division of Cardiovascular Medicine, University Hospitals/Case Western Reserve University, Cleveland, OH Department...
Conclusions: "In this proof-of-concept study, SVM is a robust method that predicts directly measured LDL-C more accurately than clinically used methods in women with and without HIV. Further studies should explore the utility in broader populations."
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Gradual increasing dyslipidemia in treatment-naive male patients with human immunodeficiency virus and treated with tenofovir plus lamivudine plus efavirenz for 3 years - Diabetology & Metabolic Syndrome
Source : https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-021-00756-y
Introduction Since the development of antiretroviral therapy (ART) with TDF plus 3TC plus EFV, this specific regimen has not been studied enough with long-term lipid and uric acid monitoring. Methods...
Conclusions:
"Gradual increasing dyslipidemia was found in male patients with human immunodeficiency virus primarily treated with tenofovir plus lamivudine plus efavirenz for 3 years. There-fore lipid metabolism parameters should be closely monitored during long-term ART with the TDF plus 3TC plus EFV regimen"
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Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol
Source : https://care.diabetesjournals.org/content/early/2021/11/16/dc21-1284
OBJECTIVE LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI...
CONCLUSIONS: "These findings suggest that the diabetogenic effect attributed to lowering LDLc is partially mediated through increased BMI. Our results could help advance understanding of adipose tissue and lipids in type 2 diabetes pathophysiology and inform strategies to reduce diabetes risk among individuals taking LDLc-lowering...
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