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Association of changes in lipid levels with changes in vitamin D levels in a real-world setting - Scientific Reports

Association of changes in lipid levels with changes in vitamin D levels in a real-world setting - Scientific Reports

Source : https://www.nature.com/articles/s41598-021-01064-1

In clinical trials, vitamin D supplementation has been reported to reduce serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) but not high-density lipoprotein cholesterol (HDL-C)....



Between-group differences in average changes in the 3 cohorts ranged from 10.71 to 12.02 mg/dL for TC, from 7.42 to 8.95 mg/dL for LDL-C, and from 21.59 to 28.09 mg/dL for TG. These differences were significant after adjusting for age, sex, race, education, body mass index, blood pressure, smoking status, geographical location, and baseline...

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Association Between Serum C1q Tumor Necrosis Factor-Related Protein 9 and the Clinical Characteristics and Prognosis of Ischemic Stroke - Neurology and Therapy

Association Between Serum C1q Tumor Necrosis Factor-Related Protein 9 and the Clinical Characteristics and Prognosis of Ischemic Stroke - Neurology and Therapy

Source : https://link.springer.com/article/10.1007/s40120-021-00296-7

Introduction C1q tumor necrosis factor (TNF)-related protein 9 (CTRP9) is a novel member of the C1q/TNF superfamily. According to our previous review, CTRP9 plays a vital role in the process...



Conclusions: All the findings indicated that serum CTRP9 could be a promising blood-derived biomarker for the early evaluation and prognosis assessment of IS.

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Cholesterol – the devil you know; ceramide – the devil you don’t

Source : https://doi.org/10.1016/j.tips.2021.10.001



Highlights:

  • Pioneering studies on cholesterol have revolutionized our understanding of the role of lipids in cardiovascular disease.
  • The widely prescribed statins inhibit cholesterol biosynthesis to prevent coronary artery disease.
  • By lowering liver cholesterol, statins reduce levels of circulating lipoproteins and decrease levels of...

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    Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms and Their Associations With Indices of Cardiometabolic Health: The CARDIA Study

    Source : https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019890



    Conclusions: Associations between apoAI and AII and cardiometabolic indices are proteoform‐specific. These results provide “proof‐of‐concept” that precise chemical characterization of human apolipoproteins will yield improved insights into the complex pathways through which proteins signify and mediate health and disease.

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    Triglyceride glucose index influences platelet reactivity in acute ischemic stroke patients - BMC Neurology

    Triglyceride glucose index influences platelet reactivity in acute ischemic stroke patients - BMC Neurology

    Source : https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02443-x

    Aim Insulin resistance was reported to increase the risk of ischemic stroke, which can be assessed by the triglyceride glucose (TyG) index. However, it remains unclear whether the TyG index...



    Conclusions: In acute ischemic stroke patients taking DAPT, the elevation of the TyG index is associated with enhanced platelet reactivity and higher prevalence of aspirin HRPR. Insulin resistance assessed by the TyG index could be an independent risk factor for aspirin HRPR.

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      Key Points • Source: BMC Neurology • Conclusion/Relevance: “In acute ischemic stroke patients taking dual antiplatelet therapy [DAPT], the elevation of the triglyceride glucose [TyG] index is associated with enhanced platelet reactivity and higher Show More