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Regulation of Lipoprotein Homeostasis by Self-Assembling Peptides

Regulation of Lipoprotein Homeostasis by Self-Assembling Peptides

Source : https://researchwith.njit.edu/en/publications/regulation-of-lipoprotein-homeostasis-by-self-assembling-peptides

High levels of serum low-density lipoprotein (LDL) cholesterol contribute to atherosclerosis, a key risk factor of cardiovascular diseases. PCSK9 is a circulatory enzyme that downregulates expression of hepatic LDL receptors,...

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  • 4yr
    PCSK9 is a circulatory enzyme that downregulates expression of hepatic LDL receptors, concomitantly increasing serum LDL-C
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Use of Lipid-Lowering Therapies Over 2 Years in GOULD, a Registry of Patients With Atherosclerotic Cardiovascular Disease in the US - PubMed

Use of Lipid-Lowering Therapies Over 2 Years in GOULD, a Registry of Patients With Atherosclerotic Cardiovascular Disease in the US - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34132735/

Of patients with ASCVD, most with suboptimal LDL-C levels at baseline, only 17.1% had LLT intensification after 2 years, and two-thirds remained at an LDL-C level greater than 70 mg/dL....

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    Guidelines for patients with atherosclerotic cardiovascular disease (ASCVD) recommend intensive statin therapy and adding nonstatin therapy if low-density lipoprotein cholesterol (LDL-C) levels are 70 mg/dL or more. Compliance with guidelines Show More
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Who sponsors this service?

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  • 4yr
    Hi there! That's a great question. Pharmaceutical manufacturers occasionally sponsor content within our communities. This allows us to provide membership free of charge, and our privacy policy safeguards your personally Show More
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4yr

Elevated Apolipoprotein A1 and HDL Cholesterol Associated with Age-related Macular Degeneration: 2 Population Cohorts - PubMed

Elevated Apolipoprotein A1 and HDL Cholesterol Associated with Age-related Macular Degeneration: 2 Population Cohorts - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33596319/

1 Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen,Denmark. 2 The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev,Denmark. 3 Department of Clinical Medicine, Faculty...

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4yr

MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia

MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia

Source : https://cdnsciencepub.com/doi/abs/10.1139/cjpp-2020-0539

Canadian Journal of Physiology and Pharmacology The present study aims to explore the role of microRNA 145-5p (miR-145-5p) in hyperlipidemia. Using bioinformatics tools and a wide range of function and...

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