The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40993712/
TyG was associated with an increased risk of all-cause and cardiovascular death in the normoglycemic subgroup, but not in the dysglycemic subgroup. In the diabetes subgroup, the association between the...
Study shows triglyceride-glucose index predicts mortality differently by metabolic status—linear risk increase in normoglycemia, U-shaped association in diabetes, none in dysglycemia—highlighting TyG as a useful, context-dependent prognostic marker.
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A practical guide to the management of dyslipidaemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41504909/
Dyslipidaemia, especially elevated low-density lipoprotein cholesterol (LDL-C), is a major modifiable risk factor for atherosclerotic cardiovascular disease (ASCVD). Dyslipidaemia remains underdiagnosed and undertreated. Dyslipidemia is highly prevalent in Germany. Even...
Dyslipidaemia, driven by elevated LDL-C and other lipids, increases ASCVD risk; management includes lifestyle changes, statins, and combination therapies, with emphasis on early diagnosis, risk modifiers, and achieving treatment targets.
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The effect of melatonin supplementation on lipid profile, oxidative stress, inflammatory marker, and sleep quality in patients with chronic kidney disease: a GRADE assessed meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41727206/
Supplementing with MLT in CKD can gently raise HDL-C levels, decrease oxidative stress, and improve sleep quality. While these effects are encouraging, more extensive and carefully planned clinical trials are...
Meta-analysis of RCTs shows melatonin in CKD modestly increases HDL, reduces oxidative stress, and improves sleep, with no significant effects on other lipids or inflammation; larger trials needed for confirmation.
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Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour extracts, flavonoids and B vitamins. A placebo-controlled, double-blind, randomized clinical trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41519619/
The combination of different FS ingredients with different mechanisms of action can be a valuable strategy for improving lipid profiles in subjects with borderline high TC and LDL-C levels.
Randomized trial shows combined Mentha spicata, Amaranthus, flavonoids, and B vitamins improve lipid profile, reducing LDL and total cholesterol while increasing HDL, especially at higher doses, in borderline dyslipidemia patients.
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Incretin polyagonists as an alternative to bariatric surgery to manage obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41884205/
Incretins are gut hormones involved in maintaining metabolic homeostasis in the human body, and disorders of the incretin system are recognized as contributing to the pathobiology of metabolic dysfunction and...
Review positions incretin polyagonists (e.g., tirzepatide) as potent non-surgical obesity alternatives to bariatric surgery, achieving comparable weight loss, glycemic control, and cardiometabolic benefits via multi-receptor gut hormone effects.
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