Conclusions: Total cholesterol, non-high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were positively associated with the presence of carotid IPN in a Chinese high-stroke-risk population. Further prospective studies should be conducted to better understand how much finding IPN adds to current stroke prediction...
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Association between small dense low-density lipoprotein cholesterol and neuroimaging markers of cerebral small vessel disease in middle-aged and elderly Chinese populations - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34753453/
The results indicate that LDL-C3 is an independent risk factor for CSVD. A new prediction model based on LDL-C3 and LDL-C4 can help clinicians identify high-risk CSVD, even in people...
Conclusion: The results indicate that LDL-C3 is an independent risk factor for CSVD. A new prediction model based on LDL-C3 and LDL-C4 can help clinicians identify high-risk CSVD, even in people with normal LDL-C levels. The levels of sdLDL-C should be considered in the assessment and management of CSVD.
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Leqvio®* (inclisiran) reduced LDL-C in people who are overweight or obese
Regardless of body mass index (BMI), Leqvio provided sustained and effective LDL-C reduction of ~50% with two doses a year**, according to pooled analysis of three Phase III studies Being...
“For patients with vascular disease who have a high BMI, physicians generally recommend weight loss in addition to cholesterol-lowering medication," said Lawrence A. Leiter, MD, Director of the Lipid Clinic, Associate Director of the Clinical Nutrition and Risk Factor Modification Centre and Associate Scientist in the Li Ka Shing Knowledge...
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Conclusions: Important differences in estimated LDL-C exist between the three equations, particularly among those with TG ≥150 mg/dL. These results in ASCVD patients, synthesized with prior evidence, raise concern that reliance upon the Friedewald and Sampson equations may result in underestimation and thus, undertreatment of LDL-C in those...
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The present study introduced a nano-targeted drug delivery approaches for PCSK9/LDLR antagonist.
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