Regulatory Non-Coding RNAs in Familial Hypercholesterolemia, Theranostic Applications
Source : https://www.frontiersin.org/articles/10.3389/fcell.2022.894800/full
Familial hypercholesterolemia (FH) is a common monogenic disease which is associated with high serum levels of low-density lipoprotein cholesterol (LDL-C) and leads to atherosclerosis and cardiovascular disease (CVD). Early diagnosis...
Relevance: In this review, we briefly discussed the mechanisms and pathophysiology of FH and novel therapeutic strategies for the treatment of FH. Moreover, the theranostic effects of different non-coding RNAs for the treatment and diagnosis of FH were highlighted. Finally, the advantages and disadvantages of ncRNA-based therapies vs....
Share
absolute cardiovascular benefits of PCSK9 inhibitors and ezetimibe added to maximally tolerated statin therapy depend on individual baseline cardiovascular risk
Source : https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac360/6631405?login=false
Comment on the article 'PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-an
Relevance: This systematic review and network meta-analysis of randomized controlled trials compared the impact of ezetimibe and proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9-i) on cardiovascular (CV) outcomes in patients taking maximally tolerated statin therapy or who were statin-intolerant.
Share
-
Amy Gonzales, Physician3yrIn patents with high to very high-risk cardiovascular risk who are on maximal dose of statin that is tolerated, adding ezetimibe and PCS9-i is recommended to achieve beneficial effects.
Retinal Microvascular Changes in Familial Hypercholesterolemia: Analysis with Swept-Source Optical Coherence Tomography Angiography - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35743656/
Familial hypercholesterolemia (FH) is a common but underdiagnosed genetic disorder affecting cholesterol metabolism, leading to atherosclerotic disease. The relationship between retinal microvascular changes and the presence of atheroma in patients...
Relevance: Familial hypercholesterolemia (FH) is a common but underdiagnosed genetic disorder affecting cholesterol metabolism, leading to atherosclerotic disease. The relationship between retinal microvascular changes and the presence of atheroma in patients with FH (FH group), and in comparison to volunteers without FH (CT group), needs...
Share
-
Amy Gonzales, Physician3yrInteresting to note that sample population belonging to the FH group are older than those in the control group although the study mentioned that this has no statistical difference. If Show More
Long-term cancer risk in heterozygous familial hypercholesterolemia relatives: a 25-year cohort study - Lipids in Health and Disease
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-022-01666-2
Background Heterozygous familial hypercholesterolemia (HeFH) due to low-density lipoprotein receptor (LDLR) mutations predisposes patients to highly elevated levels of cholesterol, and patients are at increased risk of adverse cardiovascular events...
Conclusion: In Denmark, LDLR mutation-carrying HeFH relatives did not have a different cancer risk than the general population. In contrast, nonmutation-carrying relatives had a lower risk of cancer.
Share
-
Amy Gonzales, Physician3yrInteresting study and kudos to the researchers for being able to follow-up patients long-term. Will need more studies and probably see if also applicable in other countries. This study also Show More
-
Lipid Management Connect3yrKey Takeaways • Source: Lipids in Health and Disease • Conclusion: “In Denmark, LDLR mutation-carrying HeFH relatives did not have a different cancer risk than the general population. In contrast, nonmutation-carrying relatives had a Show More
Comparative study on the performance of different classification algorithms, combined with pre- and post-processing techniques to handle imbalanced data, in the diagnosis of adult patients with familial hypercholesterolemia
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269713
Familial Hypercholesterolemia (FH) is an inherited disorder of cholesterol metabolism. Current criteria for FH diagnosis, like Simon Broome (SB) criteria, lead to high false positive rates. The aim of this...
Relevance: Familial Hypercholesterolemia (FH) is an inherited disorder of cholesterol metabolism. Current criteria for FH diagnosis, like Simon Broome (SB) criteria, lead to high false positive rates. The aim of this work was to explore alternative classification procedures for FH diagnosis, based on different biological and biochemical...
Share
-
Dr Hamid3yrFH diagnosis, based on different biological and biochemical indicators