Machine learning modelling of blood lipid biomarkers in familial hypercholesterolaemia versus polygenic/environmental dyslipidaemia

Source : https://www.nature.com/articles/s41598-021-83392-w

Familial hypercholesterolaemia increases circulating LDL-C levels and leads to premature cardiovascular disease when undiagnosed or untreated. Current guidelines support genetic testing in patients complying with clinical diagnostic criteria and cascade...

Lipid Level, Lipid Variability, and Risk of Multiple Myeloma: A Nationwide Population-Based Study of 3,527,776 Subjects - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33572660/

(1) Background: There is evidence that abnormality in lipid metabolism promotes cancer development. This study investigated whether lipid level and its variability are associated with the development of MM at...

Usefulness of Novel Martin/Hopkins and Sampson Equations over Friedewald Equation in Cardiology Outpatients: A CVSCORE-TR Substudy.

Source : https://europepmc.org/article/med/33570835

Background and aims The Friedewald equation (LDL-Cf) is known to produce inaccurate estimations of low-density lipoprotein cholesterol (LDL-C) when triglycerides are high (>400 mg/dL) or LDL-C is low (<70 mg/dL)....

Personalized medicine in lipid-modifying therapy

Source : https://doi.org/10.2217/pme-2020-0110

The choice of lipid-modifying treatment is largely based on the absolute level of cardiovascular risk and baseline lipid profile. Statins are the first-line treatment for most patients requiring reduction of...

Association of small dense LDL-cholesterol with disease severity, hypertension status and clinical outcome in patients with coronary artery disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33186323/

1 State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. 2 Department of Cardiology, Xuanwu...