A Real-World Retrospective Analysis of Secondary Prevention Patients Treated with Inclisiran over 27 Months - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40364951/
ASCVD is a global concern as it has become central to significant morbidity and mortality. LDL-C is the most important modifiable risk factor in developing ASCVD. Therefore, lowering LDL-C levels...
Inclisiran significantly reduces LDL-C (59% over 27 months) with high adherence and minimal side effects, suggesting it’s an effective long-term monotherapy or combination therapy for ASCVD risk reduction.
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Lipid dysregulation and delirium in older adults: A review of the current evidence and future directions - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40086765/
Delirium is a complex medical condition marked by acute episodes of cognitive dysfunction and behavioral disturbances, with a multifaceted etiology and challenging management across various clinical settings. Older adults, particularly...
Lipid dysregulation may contribute to delirium in older adults, particularly postoperatively, prompting interest in lipid-targeted therapies. Further research into age-related neurolipid changes is essential for novel interventions.
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Omega-3 Polyunsaturated Fatty Acids in Depression - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39201362/
Omega-3 polyunsaturated fatty acids have received considerable attention in the field of mental health, in particular regarding the treatment of depression. This review presents an overview of current research on...
Omega-3 fatty acids, especially EPA and DHA, show potential antidepressant effects, but inconsistent clinical results highlight the need for further research to establish standardized depression treatment guidelines.
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Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38762798/
ClinicalTrials.gov Identifier: NCT04291508.
In this randomized trial, IV acetaminophen was safe in sepsis patients but did not significantly increase days alive and free of organ support; some secondary organ function improvements were noted.
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Comprehensive Review of Lipid Management in Chronic Kidney Disease and Hemodialysis Patients: Conventional Approaches, and Challenges for Cardiovascular Risk Reduction - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39860649/
Background/Objectives : Lipid disorders are very prevalent in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), leading to heightened cardiovascular risk. This review examines the effectiveness of...
Lipid-lowering therapies in CKD/ESRD show limited cardiovascular benefits, especially in dialysis patients. While statins and PCSK9 inhibitors offer potential, further research is needed to optimize treatment strategies for these populations.
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