Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35276884/
This study aimed to determine how the microbiota profile might be predisposed to a better response in blood lipid profiles due to dietary fibre supplementation. A three-arm intervention study that...
Conclusion: It was concluded that the non-responsiveness to dietary fibre treatment might be mediated by the lack of ability to maintain a stable SCFA producing bacteria diversity and composition after extra fibre intake.
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Beneficial Effects of Spirulina Consumption on Brain Health - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35277035/
Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies. It is extensively utilized as a nutraceutical food supplement all over the world due to its high levels...
Conclusion/Relevance: This review focuses on the role of Spirulina in the brain, highlighting how it exerts its beneficial anti-inflammatory and antioxidant effects, acting on glial cell activation, and in the prevention and/or progression of neurodegenerative diseases, in particular Parkinson's disease, Alzheimer's disease and Multiple...
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Clinical and genetic features of sitosterolemia in Japan
Source : https://www.sciencedirect.com/science/article/abs/pii/S0009898122000808?via=ihub
We are providing clinical and genetic features of Japanese patients with sitosterolemia. * A particular missense mutation in ABCG5 accounts for 24 % of pathogenic mutation. * There are 3...
Conclusion/Relevance: We are providing a demographic overview of the clinical and genetic backgrounds of Japanese patients with sitosterolemia.
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Comparative efficacy of non-statin lipid-lowering therapies in patients with hypercholesterolemia at increased cardiovascular risk: a network meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35262430/
This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful...
Conclusions: This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful improvements in low-density lipoprotein cholesterol in patients with hypercholesterolemia on maximally...
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Efficacy and Safety of PCSK9 Monoclonal Antibodies in Patients With Diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35246337/
doi: 10.1016/j.clinthera.2021.12.005. Online ahead of print. 1 Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Sulaimani, Federal Region of Kurdistan, Iraq. 2 Cardiovascular Trials Unit, Manchester University...
Implications: PCSK9monoclonal antibodies markedly reduce LDL-C and consistently reduce cardiovascular mortality in patients with and without diabetes. Current evidence does not suggest an adverse effect of PCSK9 monoclonal antibodies on glycemic parameters.
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