A practical statin recommendation system based on real-world data to improve LDL-C management in secondary prevention
k of cardiovascular events. Owing to individual differences in statin therapy, it is possible first to consider changing the type of statin before adding non-statin medications in certain patients to...
Conclusions/Relevance: The present study demonstrated that the statin recommendation system could significantly improve the achievement of LDL-C goals in ASCVD patients, providing a new approach to improve LDL-C management.
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Lipoprotein(a) is linked to atherothrombosis and aortic valve stenosis independent of C-reactive protein - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36805188/
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Conclusion: High lipoprotein(a) was a main driver for the risk of ASCVD, myocardial infarction, and aortic valve stenosis independent of C-reactive protein levels.
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Benefit of Combination Ezetimibe/Simvastatin Among High-Risk Populations: Lessons from the IMPROVE-IT Trial - Current Atherosclerosis Reports
Source : https://link.springer.com/article/10.1007/s11883-023-01084-4
Purpose of Review The Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) demonstrated the clinical benefit of the combination of ezetimibe-simvastatin compared to placebo-simvastatin following acute coronary syndrome (ACS)....
Summary: Ezetimibe reduced the LDL-C by 16.7 mg/dL compared to placebo at 1 year, resulting in a significant reduction in the primary composite endpoint (absolute risk difference 2.0%; relative risk difference 6.4%, hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). The benefits achieved with ezetimibe in both LDL-C...
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Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36779348/
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Conclusions: In patients with atherosclerotic cardiovascular disease, long-term achievement of lower LDL-C levels, down to
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Effect of evolocumab on the progression of intraplaque neovascularization of the carotid based on contrast-enhanced ultrasonography (EPIC study): A prospective single-arm, open-label study
Source : https://www.frontiersin.org/articles/10.3389/fphar.2022.999224/full
Background and Purpose: The aim of this study was to explore the effect of half a year of evolocumab plus moderate-intensity statin treatment on carotid intraplaque neovascularization (IPN) and blood...
Conclusion: This study found that evolocumab combined with moderate-intensity statins significantly improved the blood lipid profile and reduced carotid IPN.
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