Alcohol Consumption, High-Density Lipoprotein Particles and Subspecies, and Risk of Cardiovascular Disease: Findings From the PREVEND Prospective Study
Source : https://www.mdpi.com/1422-0067/25/4/2290
The associations of HDL particle (HDL-P) and subspecies concentrations with alcohol consumption are unclear. We aimed to evaluate the interplay between alcohol consumption, HDL parameters and cardiovascular disease (CVD) risk....
Moderate alcohol consumption appears to beneficially influence levels of HDL-C, HDL-P, and other HDL parameters and is associated with a reduced risk of CVD.
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A Systematic Review and Meta-Analysis of Serum Lipid Concentrations in People With Down Syndrome
Source : https://pubmed.ncbi.nlm.nih.gov/38404114/
Individuals with DS have less favourable blood lipid concentrations than their controls, particularly HDL-C, triglycerides, and total-C, even when grouped by age. These findings underscore the importance of closer monitoring...
Those with Down syndrome exhibited less favorable lipid profiles versus those of the control group, except for total cholesterol levels, which did not cross the 200-mg/dL threshold in either group.
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The findings indicate that homozygous familial hypercholesterolemia represents a very high risk of premature ASCVD without clear sex differences, except a higher incidence of MI in men.
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Long-Term Cardiovascular Risks and the Impact of Statin Treatment on Socioeconomic Inequalities: a Microsimulation Model
Source : https://bjgp.org/content/early/2024/02/16/BJGP.2023.0198
Background UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist. Aim To present a new CVD model, and project health outcomes and the...
This study found that guideline-recommended statin treatment has good potential to reduce inequalities in health across socioeconomic status, although the reductions are larger for differences in life expectancy than for quality-adjusted life years.
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Remnant Cholesterol as a New Lipid-Lowering Target to Reduce Cardiovascular Events
Current and novel therapeutic approaches to target remnant cholesterol are discussed. Recent findings A recent Mendelian randomization study of over 12 000 000 single-nucleotide polymorphisms associated with high levels of remnant cholesterol,...
A recent Mendelian randomization study of >12 million single-nucleotide polymorphisms associated with high levels of remnant cholesterol demonstrated a genetic association between remnant cholesterol and adverse cardiovascular events among nearly 1 million participants.
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