Differences in treatment strategies for LDL-cholesterol reduction in a university lipid clinic vs. standard care apart from the use of PCSK9 inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37271601/
Treatment in a lipid clinic leads to a superior LDL-C goal achievement in very high-risk CVD patients as compared to standard care with the highest reduction under LLT with high-intensity...
Conclusion: Treatment in a lipid clinic leads to a superior LDL-C goal achievement in very high-risk CVD patients as compared to standard care with the highest reduction under LLT with high-intensity statins and ezetimibe. Referral algorithms have to be established for high-risk patients.
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Lipid Management Connect3yrKey Points • Source: Journal of Clinical Lipidology • Conclusions/Relevance: “Lipid-lowering therapy (LLT) in patients with cardiovascular disease (CVD) is insufficient despite clear guideline recommendations. Lipid clinics have specialized in patients with dyslipidemia, but Show More
Lipoprotein Particle Profiles Associated with Telomere Length and Telomerase Complex Components - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37299586/
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Conclusions/Relevance: Our results suggest that the lipoprotein profiles are associated with telomere length, TERT, and WRAP53 expression and should be considered when assessing the risk of chronic diseases.
Analysis of the evolocumab (Repatha®) patient support program for patients with cardiovascular disease in Colombia
Source : https://www.sciencedirect.com/science/article/abs/pii/S021491682300044X?via=ihub
Available online 3 June 2023 Author links open overlay panel, Mariana Pineda-Posada b , , , Show more Las enfermedades cardiovasculares son la principal causa de muerte a nivel mundial.
Conclusion: This is the first real-life study describing patient characteristics, compliance and continuity of treatment for dyslipidemia in a patient support program in Colombia. The overall adherence found was higher than 70%; similar to findings reported in other real-life studies with iPCSK9. However, the reasons for low compliance were...
A Systematic Review and Meta-Analysis on the Impact of Statin Treatment in HIV Patients on Antiretroviral Therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37174188/
The rate of new human immunodeficiency virus (HIV) infections globally is alarming. Although antiretroviral therapy (ART) improves the quality of life among this group of patients, ARTs are associated with...
Conclusions/Relevance: Finally, compared to placebo, statins significantly reduced total cholesterol (SMD: (-2.87, 95% CI: (-4.08, -1.65), p < 0.0001)). Our results suggest that the statin lipid-lowering effect in PLHIV on ART may elevate immune activation without influencing the viral load and CD4 count. However, due to the limited...
Feasibility of Short-Term Aggressive Lipid-Lowering Therapy with the PCSK9 Antibody in Acute Coronary Syndrome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37233171/
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Conclusions: In ACS patients who underwent PCI, short-term PCSK9 antibody therapy with conventional LLT was feasible in this pilot clinical trial. Long-term follow-up in a larger scale clinical trial is warranted.