Microbial metabolite-driven mechanisms linking the gut microbiome to atherosclerosis: multi-omic and translational perspectives. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42615833
Explore how gut microbiome metabolites like imidazole propionate influence atherosclerosis through vascular inflammation and plaque development, focusing on specific signaling pathways.
Gut microbiome metabolites, such as trimethylamine oxide, contribute to atherosclerosis via macrophage lipid accumulation and mTORC1 signaling activation. Disease Condition: Atherosclerosis. Specialty Focus: Cardiology.
The effect of ascorbic acid supplementation on plasma leptin and adiponectin levels: Systematic review of and studies. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42592588
Explore the impact of ascorbic acid on adiponectin and leptin levels, with varying results in human studies.
Ascorbic acid supplementation may increase adiponectin levels and potentially reduce leptin levels, though human study results present conflicting evidence regarding the effect on leptin levels.
A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42568080
Explore a microbiota-associated metabolic signature for early gestational diabetes risk stratification, offering insights into pregnancy-related cardiometabolic risk.
A three-metabolite microbiota signature, including 3-hydroxydecanoic acid, γ-Glu-Leu, and propionic acid, aids early gestational diabetes risk stratification. Specialty Focus: Endocrinology.
Amino Acid Deficiency Secondary to Continuous Venovenous Hemofiltration in Acute Decompensation of Organic Acidemias: An Anabolic Dead End? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42538737
CRRT without protein supplementation lowers plasma amino acids in organic acidemias. AA infusion may preserve anabolism, necessitating further research.
CRRT in acute decompensated OAs significantly reduces plasma amino acid concentrations. AA infusion during CRRT may aid protein anabolism. Specialty Focus: Metabolic Disorders.
Therapeutic Translation of Epicardial Adipose Tissue Targeting in Heart Failure With Preserved Ejection Fraction: How Far Are We? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42500886
Exploring the role of epicardial adipose tissue in HFpEF, this study examines therapeutic strategies, despite current gaps in targeted treatment.
EAT expansion links to HFpEF development. Reducing EAT may improve prognosis, but specific treatments remain unavailable. Modulating inflammatory response and systemic energy metabolism are beneficial strategies.