New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B: JACC Focus Seminar 1/4

Source : https://www.jacc.org/doi/full/10.1016/j.jacc.2020.11.079

Impact of Major Cardiovascular Risk Factors on the Incidence of Cardiovascular Disease among Overweight and Non-Overweight Individuals: The Circulatory Risk in Communities Study (CIRCS).

Source : https://europepmc.org/article/med/33731540

Aim We aimed to examine the impact of high-risk levels of cardiovascular risk factors on the incidence of cardiovascular disease (CVD) in overweight and non-overweight individuals without treatment for the...

A case of heterozygous familial hypercholesterolemia requiring strict low-density lipoprotein cholesterol management with proprotein convertase subtilisin/kexin 9 inhibitor after coronary artery bypass grafting

Source : https://doi.org/10.1016/j.jccase.2021.02.012

Compatibility between an overnight fasting and random cholesterol tests in Asians

Source : https://www.nature.com/articles/s41598-021-85914-y

Recent Western guidelines recommend non-fasting lipid profiles to manage dyslipidaemia. We explored its applicability to an Asian population. We determined the differences between an overnight fasting and non-fasting cholesterol profiles...

Determination of genetic scores to estimate disturbances in circulating lipid profile biomarkers of adolescents: A preliminary report

Source : https://doi.org/10.1016/j.nut.2021.111246

Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

Source : https://www.nature.com/articles/s41467-021-21553-1

The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known...

Prestroke Statins Improve Prognosis of Atrial Fibrillation-Associated Stroke through Increasing Suppressor of Cytokine Signaling-3 Levels - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33684912/

doi: 10.1159/000513767. Online ahead of print. 1 Department of Neurology, Chengdu Second People's Hospital, Chengdu, China, [email protected]. 2 Department of Neurology, Nanchong Central Hospital, Nanchong, China. 3 Department of Neurology,...

Hyperlipidemia: effective disease management with a focus on PCSK9 inhibitors - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33710845/

Hyperlipidemia is a prevalent condition in the United States and a significant contributor to atherosclerotic cardiovascular disease (ASCVD). ASCVD is a primary cause of morbidity and mortality in the United...

Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33663735/

These pooled safety and efficacy data show that inclisiran, given twice yearly in addition to maximally tolerated statin therapy with or without other LDL-C lowering agents, is an effective, safe,...

Patients Living With HIV Are Less Likely to Receive Appropriate Statin Therapy for Cardiovascular Disease Risk Reduction - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33678059/

Our study reveals that PLWH may be at a disadvantage in receiving appropriate statin therapy for ASCVD risk reduction. This is important given the heightened risk for ASCVD in this...

Diet Quality Indices and Their Correlation with Glycemic Status and Lipid Profile in Patients with Type 2 Diabetes

Source : https://doi.org/10.1155/2021/2934082

Background . The study aimed to determine the correlation between different diet quality indices and glycemic status and lipid profile in patients with diabetes. Methods .

PCSK9 Levels and Metabolic Profiles in Elderly Subjects with Different Glucose Tolerance under Statin Therapy

Source : https://www.mdpi.com/2077-0383/10/5/994/html

Proprotein convertase subtilisin/kexin type 9 (PCSK9) degrades low-density lipoprotein cholesterol (LDL-C) receptors, and thus regulates the LDL-C levels in the circulation. Type 2 diabetics often have elevated LDL-C levels. However,...

Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis

Source : https://doi.org/10.1016/j.jacc.2020.12.058

Consumption of bitter apricot seeds affects lipid and endocrine profile in women

Source : https://doi.org/10.1080/03601234.2021.1890513

Abstract Natural products have been attracting increasing attention in human diet, both due to the possible negative effects of synthetic food additives on human health and the increased consumer perception....

Effects of consumption of a low glycaemic index formula on glycaemic control in patients with type 2 diabetes managed by medical nutrition therapy

Source : https://dx.doi.org/10.1590/fst.51320

Original Article Effects of consumption of a low glycaemic index formula on glycaemic control in patients with type 2 diabetes managed by medical nutrition therapy Department of Nutrition, the Second...

Inclisiran: A Game Changer in a Changing Game?∗

Source : https://www.jacc.org/doi/full/10.1016/j.jacc.2021.01.008

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials

Source : https://www.bmj.com/content/372/bmj.n135

Objective To establish the effect of statins on muscle symptoms in people who had previously reported muscle symptoms when taking statins. Design Series of randomised, placebo controlled n-of-1 trials. Setting...

Inference of a causal relation between low-density lipoprotein cholesterol and hypertension using mendelian randomization analysis

Source : https://clinicalhypertension.biomedcentral.com/articles/10.1186/s40885-021-00162-6

Background It is known in some studies that higher the LDL-C, the greater the risk of developing cardiovascular disease. However, studies of the causal effects between LDL-C and hypertension are...