6mo
6mo
Air pollution and atherosclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40411956/
Air pollution is associated with considerable cardiovascular mortality and morbidity. The vascular disease atherosclerosis underlies many cardiovascular conditions, with atherosclerotic plaque rupture being a trigger for stroke and myocardial infarction....
Air pollution contributes significantly to atherosclerosis development and progression, increasing cardiovascular risks. This review highlights epidemiological links, biological mechanisms, and urges urgent action to mitigate pollution-related cardiovascular disease.
6mo
ADA 2025 Highlights: Obesity Therapies, Islet Cell Advances, and Oral GLP-1 Outcomes in T2D
At ADA 2025, Dr. Mark Atkinson (University of Florida Diabetes Institute) highlighted the systemic benefits of obesity-targeted therapies, including cardiometabolic and cognitive improvements, while noting concerns about implementation and potential muscle loss. Emerging advances in stem cell–derived islet transplantation for type 1 diabetes show promise in reducing insulin dependence. Dr. John Buse (University of North Carolina) presented SOUL trial data indicating that oral GLP-1 receptor agonist therapy reduced major adverse cardiovascular events—CV death, nonfatal MI, or stroke—by 14%, with additional reductions in limb complications in high-risk patients with type 2 diabetes.
6mo
Possible Involvement of Lysophospholipids in Severe Asthma as Novel Lipid Mediators - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40001485/
In severe asthma, symptoms are unstable despite intensive treatment based on high doses of inhaled corticosteroids and on-demand use of oral corticosteroids. Although, recently, various biological agents related to Th2...
Severe asthma remains poorly controlled despite current therapies. Lysophospholipids, acting independently of Type 2 inflammation, may drive corticosteroid resistance and airway dysfunction, offering promising new targets for precision asthma treatment.
6mo
Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40069786/
Lipid signatures in MDD, BD, and SCZ shed light on underlying processes. Further research is needed to validate biomarkers and refine their clinical applications in precision psychiatry.
This review links altered lipid profiles and lipid-related genes to major psychiatric disorders, highlighting shared biomarkers and pathways, with potential for advancing precision psychiatry and clinical biomarker development.