Long-term effects of evolocumab in participants with HIV and dyslipidemia: results from the open-label extension period - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35025817/
doi: 10.1097/QAD.0000000000003175. Online ahead of print. 1 Sorbonne Université, GRC no.
Conclusion: Long-term administration of evolocumab lowered LDL-C and non-HDL-C, allowing more PWH to achieve recommended lipid goals with no serious adverse events.
Sex differences in low-density lipoprotein cholesterol reduction with PCSK9 inhibitors in real world patients: the LIPID-REAL Registry - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34983910/
doi: 10.1097/FJC.0000000000001205. Online ahead of print. 1 Cardiology Department. Hospital Universitario de San Juan. Alicante, Spain Unidad de Investigación en Cardiología. Fundación para el Fomento de la Investigación Sanitaria y...
Conclusion: This multicentre and retrospective registry of real-world patients treated with PCSK9 inhibitors highlights significant gender differences in LDLc reduction.
Molecular genetics for familial hypercholesterolemia
Source : https://imrpress.com/journal/RCM/23/1/10.31083/j.rcm2301004
IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science....
Conclusion/Relevance: "These results permit the following conclusions: (a) when participants were solely ascertained for abnormal LDL cholesterol level (>190 mg/dL), we identified an FH mutation in 25.05% of hypercholesterolemic patients. These sequencing yelds are partially overlapping with other previous screening studies [7, 8]; (b) CAD...
Laparoscopic diagnosis of idiopathic left ovarian vein thrombosis in a 27-year-old woman - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35096407/
Idiopathic left ovarian vein thrombosis was diagnosed in a 27-year-old woman at the time of a diagnostic laparoscopy performed because of a suspected ovarian torsion. The diagnosis was confirmed by...
Relevance: During follow-up it became clear that the patient was already diagnosed with familial hypercholesterolemia before the occurrence of the ovarian vein thrombosis. It remains unclear if familial hypercholesterolemia played a role in the occurrence of ovarian vein thrombosis in our patient.
THE EFFECT OF EVOLOCUMAB ALONE AND IN COMBINATION WITH ATORVASTATIN ON LIPID PROFILE - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35058387/
Conclusions: Preproteins convert as esubtilisin/kexin type 9 inhibitor regulates the serum levels of lipid and cholesterol by lowering LDL-C, and the results also indicate that combination of evolocumab and atorvastatin...
Conclusion: Preproteins convert as esubtilisin/kexin type 9 inhibitor regulates the serum levels of lipid and cholesterol by lowering LDL-C, and the results also indicate that combination of evolocumab and atorvastatin are more potent in lowering the lipid profile and then reduce progression of atherosclerosis than evolocumab alone in rabbits...