Role of PCSK9 inhibitors in the management of dyslipidaemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38195006/
Proprotein convertase subtilisin kexin9 (PCSK9) inhibitors are novel agents that lower LDL cholesterol and reduce cardio-vascular event rate. Being expensive, these agents are reserved for those with high risk or...
PCSK9 inhibitors lower LDL cholesterol and cardiovascular event rates, reserved for high-risk patients with inadequate responses to statins and ezetimibe or those intolerant to statins due to high cost.
Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for Cardiovascular Disease Prevention - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38068483/
Over the last half-century, discussions on the exact targets for low-density lipoprotein cholesterol (LDL-C) reduction have evolved towards a more aggressive approach with lower LDL-C targets, particularly for high-risk patients...
This paper reviews the evolution of LDL-C targets in lipid management, highlighting the efficacy of statins and newer therapies in reducing ASCVD risk and advocating for lower LDL-C goals.
Bempedoic Acid: Lipid Lowering for Cardiovascular Disease Prevention - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38419721/
The management of low-density lipoprotein cholesterol (LDL-C) levels is a central strategy for the prevention of atherosclerotic cardiovascular disease. Current United States (2018 American Heart Association/American College of Cardiology/Multisociety) and...
Bempedoic acid effectively lowers LDL-C and reduces major cardiovascular events in high-risk patients with statin intolerance, showing significant benefits while having fewer myalgia and diabetes events compared to placebo.
Comprehensive review on ethnomedicinal, phytochemistry and pharmacological profile of - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39380237/
Ficus religiosa L. ( F. religiosa ) or sacred fig is a large perennial tree belonging to the family Moraceae or mulberry family. Though the tree has pan-tropical distribution but...
Ficus religiosa, or sacred fig, is a medicinal tree with diverse bioactive compounds, traditionally used to treat various ailments. Future research should focus on its structure-function relationships and signaling pathways.
Effect of lipid-lowering therapy on platelet reactivity in patients treated with and without antiplatelet therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37870424/
Circulating lipoproteins may interact with platelets, increasing platelet sensitivity to aggregating agonists and their tendency towards activation and thrombus formation. In particular, patients with hypercholesterolemia exhibit a higher degree of...
Lipid-lowering therapies reduce platelet reactivity and thrombus formation, improving clinical outcomes. This review highlights the mechanisms, effects of various therapies, and emphasizes future research needs in optimizing platelet function management.