Clinical decision support for familial hypercholesterolemia (CDS-FH): Rationale and design of a cluster randomized trial in primary care
Source : https://www.sciencedirect.com/science/article/pii/S000287032200031X?via=ihub
Familial hypercholesterolemia (FH) is an underdiagnosed and undertreated genetic disorder with high risk of premature atherosclerotic cardiovascular disease and death. Clinical decision support (CDS) systems have the potential to aid...
Conclusion: Despite increasing awareness of FH, the condition remains underdiagnosed and undertreated. The present study will investigate whether a CDS can increase the number of patients being diagnosed with FH.
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Low density lipoprotein cholesterol levels exceed the recommended European threshold for PCSK9i initiation: lessons from the HEYMANS study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35175350/
Across Europe, LDL-C levels at evolocumab initiation were three times higher than recommended thresholds for PCSK9i initiation, reflecting disparities between implementation and guidelines. More patients attained risk-based LDL-C goals when...
Conclusions: Across Europe, LDL-C levels at evolocumab initiation were three times higher than recommended thresholds for PCSK9i initiation, reflecting disparities between implementation and guidelines. More patients attained risk-based LDL-C goals when receiving evolocumab in combination with LLT versus those not receiving combination...
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Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial
Source : https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003883
Richard S. Legro, Karl R. Hansen, Michael P. Diamond, Anne Z. Steiner, Christos Coutifaris, Marcelle I. Cedars, Kathleen M. Hoeger, Rebecca Usadi, Erica B. Johnstone, Daniel J. Haisenleder Subject Areas...
Conclusions: A preconception intensive lifestyle intervention for weight loss did not improve fertility or birth outcomes compared to an exercise intervention without targeted weight loss. Improvement in metabolic health may not translate into improved female fecundity.
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Dr Hamid4yrImprovement in metabolic health Should be discussed with women -
Michelle Jardine4yrI see so many obese women with problems with fertility and often with weight loss and control of their obesity taking conceive
PCSK9 promotes arterial medial calcification
Source : https://www.atherosclerosis-journal.com/article/S0021-9150(22)00029-6/fulltext
PCSK9 plasma levels are negatively associated with glomerular filtration rate, and atherosclerotic cardiovascular disease further increased PCSK9 plasma levels in a cohort of 594 subjects. * PCSK9 plasma levels are...
Conclusions: Our study reveals a direct role of PCSK9 on vascular calcification induced by higher inorganic phosphate levels associated with renal impairment. This effect appears to be mediated by a switch towards a pro-calcific phenotype of SMCs associated with the release of EVs containing Ca2 and ALP.
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Dr Hamid4yrPCSK9 plasma levels are negatively associated with glomerular filtration rate, and atherosclerotic cardiovascular disease- interesting read
Sex-specific endothelial dysfunction induced by high-cholesterol diet in rats: The role of protein tyrosine kinase and nitric oxide - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35144857/
1 Health Clinical Science Research Center, Zahedan Branch, Islamic Azad University, Zahedan, Iran; Student Research Committee, Islamic Azad University, Zahedan Branch, Zahedan, Iran. 2 Imam Zaman Hospital, Mashad, Iran. 3...
Conclusion: HC diet alters endothelium function through Nitric oxide (NO) and tyrosine kinase pathways in male rats.
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Dr Hamid4yrAtherosclerosis is a chronic process playing a crucial role in the pathogenesis of cardiovascular disease