Host immunomodulatory lipids created by symbionts from dietary amino acids - Nature
Source : https://www.nature.com/articles/s41586-021-04083-0
Small molecules derived from symbiotic microbiota critically contribute to intestinal immune maturation and regulation1. However, little is known about the molecular mechanisms that control immune development in the host-microbiota environment....
We present a structural and molecular-level paradigm of immunomodulatory control by interactions of endobiotic metabolites with diet, microbiota and the immune system.
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International Journal of Medical Biochemistry
Source : https://internationalbiochemistry.com/jvi.aspx?pdir=ijmb&plng=eng&un=IJMB-28190&look4=
Int J Med Biochem . Ahead of Print: IJMB-28190 Hacer Eroğlu 1, Arif Murat Kaytaz 2, Evin Ademoglu 2, Sema Genc 3 1Istanbul Bakırköy Prof.Dr.Mazhar Osman Mental Health And Nerve...
Discussion and Conclusion: This study emphasizes the importance of determining lipid profiles during childhood and adolescence and taking preventive actions for cardiovascular diseases by implementing reliable age- and sex-specific cutoff values.
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Polygenic contribution for familial hypercholesterolemia (FH) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34751168/
Polygenic risk scores have revealed to be important tools to define the cause of hypercholesterolemia in FH mutation-negative individuals and should be included in FH diagnosis strategies, although there is...
Summary: Polygenic risk scores have revealed to be important tools to define the cause of hypercholesterolemia in FH mutation-negative individuals and should be included in FH diagnosis strategies, although there is still space for more specific LDL-C GRS to be developed. The use of GRS may be used to refine cardiovascular risk prediction in FH...
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Conclusions: Total cholesterol, non-high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were positively associated with the presence of carotid IPN in a Chinese high-stroke-risk population. Further prospective studies should be conducted to better understand how much finding IPN adds to current stroke prediction...
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Association between small dense low-density lipoprotein cholesterol and neuroimaging markers of cerebral small vessel disease in middle-aged and elderly Chinese populations - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34753453/
The results indicate that LDL-C3 is an independent risk factor for CSVD. A new prediction model based on LDL-C3 and LDL-C4 can help clinicians identify high-risk CSVD, even in people...
Conclusion: The results indicate that LDL-C3 is an independent risk factor for CSVD. A new prediction model based on LDL-C3 and LDL-C4 can help clinicians identify high-risk CSVD, even in people with normal LDL-C levels. The levels of sdLDL-C should be considered in the assessment and management of CSVD.
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