Complicated Treatment Course of Severe Asymptomatic Hypertriglyceridemia: A Case Report and Literature Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38620025/
BACKGROUND Close observation, statins, fibrate treatment, and lifestyle changes can safely manage asymptomatic individuals with severe hypertriglyceridemia (HTG) and minimal risk of symptom development. However, the risk of medication-induced liver...
A 43-year-old man with severe asymptomatic hypertriglyceridemia developed acute liver injury from statin-fibrate therapy. Management required insulin, fibrate adjustment, and lifestyle changes, emphasizing the need for careful monitoring and further research.
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Fat and fatty acids - a scoping review for Nordic Nutrition Recommendations 2023 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38327998/
Two de novo NNR2022 systematic reviews (SRs) as well as 21 qualified SRs (qSRs) were available. A literature search yielded an additional ~70 SRs, meta-analyses and biomarker papers. Diets lower...
Dietary fat type impacts health outcomes, with PUFAs improving lipid profiles, reducing CVD and diabetes risk, and long-chain n-3 PUFAs lowering triglycerides and cancer risks. Trans fats worsen lipid profiles and CVD.
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The Lipid-Heart Hypothesis and the Keys Equation Defined the Dietary Guidelines but Ignored the Impact of Trans-Fat and High Linoleic Acid Consumption - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38794685/
In response to a perceived epidemic of coronary heart disease, Ancel Keys introduced the lipid-heart hypothesis in 1953 which asserted that high intakes of total fat, saturated fat, and cholesterol...
Ancel Keys' 1953 lipid-heart hypothesis linked fat intake to heart disease risk. However, studies failed to validate it, while cancer and metabolic disorders increased, highlighting the limitations of this approach.
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This network meta-analysis evaluates the efficacy of GLP-1RAs in type 2 diabetes, finding tirzepatide most effective for glycaemic control, and CagriSema for weight loss, with concerns over gastrointestinal adverse events at high doses.
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Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38506081/
P/LP variants in LDLR are common. Expanding the use of reproductive carrier screening to include genes associated with FH presents another opportunity to identify people predisposed to cardiovascular disease.
A study on female reproductive carrier screening found that pathogenic LDLR variants, linked to familial hypercholesterolemia, are common, with higher frequency in Asian populations, offering opportunities for early cardiovascular disease identification.
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