Concomitant use of statins and sodium-glucose co-transporter 2 inhibitors and the risk of myotoxicity reporting - A disproportionality analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36912450/
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Conclusion: There was no increased risk of myotoxicity reporting associated with concomitant use of SGLT2i and statins or for specific drug pairs.
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The association between PCSK9 inhibitor use and sepsis - A systematic review and meta-analysis of 20 double-blind, randomized, placebo-controlled trials
Source : https://www.amjmed.com/article/S0002-9343(23)00144-4/fulltext
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are novel, potent lipid-lowering therapies that have been recommended for patients with familial hypercholesterolemia or those with established cardiovascular disease (CVD) for CVD...
Conclusion: There was neither a beneficial nor a harmful association between PCSK9 inhibitors and risk of sepsis or severe infections. These findings provide reassurance regarding the safety of PCSK9 inhibitors in patients who are concerned about potential drug side effects related to infections.
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Clinical characteristics and outcomes of Chinese patients with coronary heart disease and resistant hypertension - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36929173/
There is currently few research on clinical characteristics and outcomes of coronary heart disease (CHD) with resistant hypertension in central region of China. This study aimed to assess the risk...
Conclusion: Resistant hypertension was a quite common and high proportion finding in patients with CHD and hypertension in central region of China, and these patients have a worse clinical prognosis.
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Coronary artery calcium, hepatic steatosis, and atherosclerotic cardiovascular disease risk in patients with type 2 diabetes mellitus: Results from the Dallas heart study
Source : https://www.sciencedirect.com/science/article/abs/pii/S0033062023000270?via=ihub
Available online 15 March 2023 Author links open overlay panel, Jennifer Linge b c , Olof D. Leinhard b c , , , , , , Ian J. Neeland a...
Conclusions: In the DHS, we found that CAC was associated with ASCVD risk independent of T2D status. We did not observe an association between HTC and ASCVD in participants without T2D, but there was an inverse association between HTC and ASCVD in those with T2D that was replicated in the UKB cohort. Further investigation is warranted to...
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A Review of Low-Density Lipoprotein-Lowering Diets in the Age of Anti-Sense Technology - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36904248/
This narrative review discusses an important issue, the primary role of diet in reducing low-density lipoprotein cholesterol (LDLc) concentrations in polygenic hypercholesterolemia. Two effective drugs, statins, and ezetimibe, that lower...
Conclusions/Relevance: Foods such as nuts and brans, especially within a prudent, plant-based diet low in saturates complemented by supplements such as phytosterols, have the potential to reduce LDLc further. A combination of such foods has been shown to lower LDLc by 20%. A nutritional approach requires backing from industry to develop and...
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Cardiologist Connect3yrKey Points • Source: MDPI • Conclusions/Relevance: “Foods such as nuts and brans, especially within a prudent, plant-based diet low in saturates complemented by supplements such as phytosterols, have the potential to reduce LDLc Show More