Conclusion: "This study demonstrated that both low and high levels of LDL-C were associated with a higher risk of diabetes diagnosis. Patients with either high or low LDL-C may need to be closely monitored for the risk of diabetes."
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Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia: a post hoc analysis of efficacy and glycaemic control using pooled data from phase 3 clinical trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34981622/
doi: 10.1111/dom.14645. Online ahead of print. 1 Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. 2 Medical University of Łódź, Łódź, Poland. 3 University...
Conclusion: Bempedoic acid significantly lowered LDL-C across glycaemic strata and did not worsen glycaemic parameters nor increase incidence of new-onset diabetes vs placebo over a median follow-up of 1 year. This article is protected by copyright. All rights reserved.
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Relationship between adiponectin and intramuscular fat content determined by ultrasonography in older adults
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262271
Age-associated intramuscular adipose tissue (IntraMAT) deposition induces the development of insulin resistance and metabolic syndrome. However, the relationship between IntraMAT and biochemical parameters in older adults remains unclear. The purpose...
"These data suggest that adiponectin level is related to IntraMAT content, independent of VAT in normal-weight older adults. The dynamics of adiponectin might not be similar to those of other circulating biochemical parameters in older men and women. "
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Addressing dyslipidemic risk beyond LDL-cholesterol
Source : https://www.jci.org/articles/view/148559
Open Access | Review Series 10.1172/JCI148559 1 Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York, USA. 2 Division of Endocrinology, Diabetes and Metabolism, Department of...
Apolipoprotein C3 (APOC3) and angiopoietin-like 3 (ANGPTL3) have emerged as targets for inhibition by antibody, antisense, or RNAi approaches. Inhibition of either molecule lowers TRL but respectively raises or lowers HDL levels. Large clinical trials of such agents in patients with high CVD risk and elevated levels of TRL will be required to...
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Conclusion: "Tamoxifen can alter the lipid profile in females, particularly by decreasing TC, LDL-C and HDLsingle bondC. Tamoxifen can further reduce TC and LDL-C if the dose of administration is ≥20 mg/day, the treatment duration is ≤52 weeks and if it prescribed in subjects with dyslipidemia."
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