Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39859502/
Diets rich in carbohydrate and saturated fat contents, when combined with a sedentary lifestyle, contribute to the development of obesity and metabolic syndrome (MetS), which subsequently increase palmitic acid (PA)...
Palmitic acid (PA)-induced lipotoxicity in obesity and MetS involves ER stress, mitochondrial dysfunction, and ROS. Protective mechanisms include FFAR activation, lipid droplet storage, and antioxidants to counteract oxidative damage and dysfunction.
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Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38464721/
Dysregulated lipid metabolism is implicated in the pathophysiology of a range of kidney diseases. The specific mechanisms through which lipotoxicity contributes to acute kidney injury (AKI) remain poorly understood. Herein...
Lipotoxicity in ischemic acute kidney injury involves lipid accumulation and mitochondrial dysfunction. A novel "immunometabolic" lipotoxicity mechanism is explored, highlighting potential therapeutic strategies using lipid-lowering medications to mitigate kidney damage.
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Lipid-based systems with precipitation inhibitors as formulation approach to improve the drug bioavailability and/or lower its dose: a review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38815207/
Lipid-based systems, such as self-microemulsifying systems (SMEDDS) are attracting strong attention as a formulation approach to improve the bioavailability of poorly water-soluble drugs. By applying the "spring and parachute" strategy...
Supersaturable SMEDDS enhance bioavailability of poorly soluble drugs by maintaining supersaturation using polymers like hypromellose. This approach enables smaller doses, reduced GI irritation, and improved pediatric and elderly formulations.
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Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38542042/
Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent...
A meta-analysis of 15 studies (1708 patients) found that letrozole and exemestane negatively impact lipid profiles in postmenopausal breast cancer patients, warranting monitoring, especially in those with cardiovascular risk factors.
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Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38392971/
Lipids are a crucial component of the human brain, serving important structural and functional roles. They are involved in cell function, myelination of neuronal projections, neurotransmission, neural plasticity, energy metabolism,...
Lipids play critical roles in brain function and may serve as blood biomarkers for mental illnesses, though further research is needed to clarify their diagnostic potential and effects of psychiatric medications.
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