Source : https://pubmed.ncbi.nlm.nih.gov/38794685/
In response to a perceived epidemic of coronary heart disease, Ancel Keys introduced the lipid-heart hypothesis in 1953 which asserted that high intakes of total fat, saturated fat, and cholesterol...
Ancel Keys' 1953 lipid-heart hypothesis linked fat intake to heart disease risk. However, studies failed to validate it, while cancer and metabolic disorders increased, highlighting the limitations of this approach.
This network meta-analysis evaluates the efficacy of GLP-1RAs in type 2 diabetes, finding tirzepatide most effective for glycaemic control, and CagriSema for weight loss, with concerns over gastrointestinal adverse events at high doses.
Source : https://pubmed.ncbi.nlm.nih.gov/38506081/
P/LP variants in LDLR are common. Expanding the use of reproductive carrier screening to include genes associated with FH presents another opportunity to identify people predisposed to cardiovascular disease.
A study on female reproductive carrier screening found that pathogenic LDLR variants, linked to familial hypercholesterolemia, are common, with higher frequency in Asian populations, offering opportunities for early cardiovascular disease identification.
This review highlights key advancements in understanding how lipid metabolism and complement dysregulation contribute to Age-related Macular Degeneration (AMD). Emerging evidence supports a dual-targeted therapeutic approach combining lipid modulators with complement inhibitors to improve patient outcomes.
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