Source : https://pubmed.ncbi.nlm.nih.gov/38506081/
P/LP variants in LDLR are common. Expanding the use of reproductive carrier screening to include genes associated with FH presents another opportunity to identify people predisposed to cardiovascular disease.
A study on female reproductive carrier screening found that pathogenic LDLR variants, linked to familial hypercholesterolemia, are common, with higher frequency in Asian populations, offering opportunities for early cardiovascular disease identification.
This review highlights key advancements in understanding how lipid metabolism and complement dysregulation contribute to Age-related Macular Degeneration (AMD). Emerging evidence supports a dual-targeted therapeutic approach combining lipid modulators with complement inhibitors to improve patient outcomes.
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Source : https://pubmed.ncbi.nlm.nih.gov/38397362/
Familial hypercholesterolemia is a genetically determined disease characterized by elevated plasma total and LDL cholesterol levels from the very first years of life, leading to early atherosclerosis. Nutritional intervention is...
This review examines nutritional interventions and nutraceuticals for treating dyslipidemia in childhood, focusing on lipid-lowering supplements, their mechanisms, and the benefits and risks in pediatric patients with severe dyslipidemia.