Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38642715/
Alzheimer's and Parkinson's diseases are two of the most frequent neurological diseases. The clinical features of AD are memory decline and cognitive dysfunction, while PD mainly manifests as motor dysfunction...
Dysregulated lipid metabolism exacerbates Alzheimer's and Parkinson's diseases through various mechanisms, with emerging lipid-targeting therapies, like PPAR agonists and ApoE monoclonal antibodies, offering potential for treatment and prevention.
Share
Lipid metabolism disorder in diabetic kidney disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38742197/
Diabetic kidney disease (DKD), a significant complication associated with diabetes mellitus, presents limited treatment options. The progression of DKD is marked by substantial lipid disturbances, including alterations in triglycerides, cholesterol,...
This research investigates the connection between lipid metabolism disturbances and diabetic kidney disease (DKD), highlighting mechanisms like ferroptosis, lipophagy, and immune modulation, offering new therapeutic pathways for DKD management.
Share
Repeated implants failure in young patient with idiopathic nephrotic syndrome: a case report with brief review of the literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38183071/
Clinical practice guidelines are needed for the management of dental implants in chronic steroid users.
This case report highlights implant failure in a 20-year-old female with idiopathic nephrotic syndrome, long-term steroid use, and its impact on bone metabolism and osseointegration, emphasizing the need for specific clinical guidelines.
Share
Complicated Treatment Course of Severe Asymptomatic Hypertriglyceridemia: A Case Report and Literature Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38620025/
BACKGROUND Close observation, statins, fibrate treatment, and lifestyle changes can safely manage asymptomatic individuals with severe hypertriglyceridemia (HTG) and minimal risk of symptom development. However, the risk of medication-induced liver...
A 43-year-old man with severe asymptomatic hypertriglyceridemia developed acute liver injury from statin-fibrate therapy. Management required insulin, fibrate adjustment, and lifestyle changes, emphasizing the need for careful monitoring and further research.
Share
Fat and fatty acids - a scoping review for Nordic Nutrition Recommendations 2023 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38327998/
Two de novo NNR2022 systematic reviews (SRs) as well as 21 qualified SRs (qSRs) were available. A literature search yielded an additional ~70 SRs, meta-analyses and biomarker papers. Diets lower...
Dietary fat type impacts health outcomes, with PUFAs improving lipid profiles, reducing CVD and diabetes risk, and long-chain n-3 PUFAs lowering triglycerides and cancer risks. Trans fats worsen lipid profiles and CVD.
Share