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Innovative Cardiovascular Research Insights at AHA’s 100th Anniversary

At the American Heart Association’s centennial conference, Dr. Amit Khera, Director of Preventive Cardiology and Professor at UT Southwestern Medical Center, and Dr. John L. Sapp, Assistant Dean of Clinical Research at Dalhousie University, presented key findings. Topics included Tirzepatide’s impact on HFpEF and obesity, the comparison of left atrial appendage closure versus anticoagulation for atrial fibrillation, intensive blood pressure control in diabetes, and insights from the VANISH2 trial on ventricular tachycardia. These findings provide healthcare professionals with evidence-based strategies to advance cardiovascular care.

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Clinical practice recommendations on lipoprotein apheresis for children with homozygous familial hypercholesterolaemia: An expert consensus statement from ERKNet and ESPN - PubMed

Clinical practice recommendations on lipoprotein apheresis for children with homozygous familial hypercholesterolaemia: An expert consensus statement from ERKNet and ESPN - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38598969/

Homozygous familial hypercholesterolaemia is a life-threatening genetic condition, which causes extremely elevated LDL-C levels and atherosclerotic cardiovascular disease very early in life. It is vital to start effective lipid-lowering treatment...

Homozygous familial hypercholesterolemia requires early lipid-lowering treatment. Lipoprotein apheresis effectively reduces LDL-C, but guidelines are limited. A consensus statement offers practical guidance on its use in children with this condition.

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Cost-Effectiveness of Screening Strategies for Familial Hypercholesterolaemia: An Updated Systematic Review - PubMed

Cost-Effectiveness of Screening Strategies for Familial Hypercholesterolaemia: An Updated Systematic Review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38265575/

Based on reported willingness to pay thresholds for each setting, most CEA studies concluded that screening for FH compared with no screening was cost-effective, regardless of the screening strategy. Cascade...

This review synthesizes cost-effectiveness of familial hypercholesterolemia screening strategies, finding cascade screening most cost-effective, with long-term lipid-lowering treatment costs as a key ICER driver. Most strategies were cost-effective compared to no screening.

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American Heart Association Scientific Sessions

The American Heart Association 2024 Scientific Sessions were held at the McCormick Place Convention Center in Chicago from Nov. 16 to 18. More than 15,000 attendees were at the meeting via virtual stream or in-person. Click above to find our postconference wrap-up report with insights on new therapies and advances in preventing, diagnosing, and treating cardiovascular disease.

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Targeting dysregulated lipid metabolism in the tumor microenvironment - PubMed

Targeting dysregulated lipid metabolism in the tumor microenvironment - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38060103/

The reprogramming of lipid metabolism and its association with oncogenic signaling pathways within the tumor microenvironment (TME) have emerged as significant hallmarks of cancer. Lipid metabolism is defined as a...

Lipid metabolism dysregulation in the tumor microenvironment influences cancer progression. This review explores mechanisms of lipid reprogramming, its role in oncogenesis, and emerging therapies targeting lipid metabolism for cancer treatment.

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