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Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for Cardiovascular Disease Prevention - PubMed

Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for Cardiovascular Disease Prevention - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38068483/

Over the last half-century, discussions on the exact targets for low-density lipoprotein cholesterol (LDL-C) reduction have evolved towards a more aggressive approach with lower LDL-C targets, particularly for high-risk patients...

This paper reviews the evolution of LDL-C targets in lipid management, highlighting the efficacy of statins and newer therapies in reducing ASCVD risk and advocating for lower LDL-C goals.

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Bempedoic Acid: Lipid Lowering for Cardiovascular Disease Prevention - PubMed

Bempedoic Acid: Lipid Lowering for Cardiovascular Disease Prevention - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38419721/

The management of low-density lipoprotein cholesterol (LDL-C) levels is a central strategy for the prevention of atherosclerotic cardiovascular disease. Current United States (2018 American Heart Association/American College of Cardiology/Multisociety) and...

Bempedoic acid effectively lowers LDL-C and reduces major cardiovascular events in high-risk patients with statin intolerance, showing significant benefits while having fewer myalgia and diabetes events compared to placebo.

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Comprehensive review on ethnomedicinal, phytochemistry and pharmacological profile of - PubMed

Comprehensive review on ethnomedicinal, phytochemistry and pharmacological profile of - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39380237/

Ficus religiosa L. ( F. religiosa ) or sacred fig is a large perennial tree belonging to the family Moraceae or mulberry family. Though the tree has pan-tropical distribution but...

Ficus religiosa, or sacred fig, is a medicinal tree with diverse bioactive compounds, traditionally used to treat various ailments. Future research should focus on its structure-function relationships and signaling pathways.

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Effect of lipid-lowering therapy on platelet reactivity in patients treated with and without antiplatelet therapy - PubMed

Effect of lipid-lowering therapy on platelet reactivity in patients treated with and without antiplatelet therapy - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37870424/

Circulating lipoproteins may interact with platelets, increasing platelet sensitivity to aggregating agonists and their tendency towards activation and thrombus formation. In particular, patients with hypercholesterolemia exhibit a higher degree of...

Lipid-lowering therapies reduce platelet reactivity and thrombus formation, improving clinical outcomes. This review highlights the mechanisms, effects of various therapies, and emphasizes future research needs in optimizing platelet function management.

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Mitochondrial DNA (mtDNA) plays a crucial role in cellular energy, and its maintenance is tied to lipid metabolism. Disruptions in lipid homeostasis can affect mtDNA integrity, leading to metabolic diseases. Targeting lipid trafficking and metabolism could offer new treatments for mitochondrial disorders.

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