Effects of Proprotein Convertase Subtilisin-Kexin Type 9 Inhibitors on Inflammatory and Hemostatic Parameters in Post Myocardial Infarction Patients
Source : https://pubmed.ncbi.nlm.nih.gov/38070635/
Despite progress in treatment, elevated levels of low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) (Lp(a)), represent a significant part of the residual risk. Both are associated with inflammation and the...
These results show that inflammatory cytokines and fibrinolytic parameters are related to LDL-C and not Lp(a) in patients postmyocardial infarction before and with neither of them following PCSK9 inhibitor treatment.
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Significant Gap Between Guidelines and Practice in the Management of LDL Cholesterol: Insight From the Survey of the Korean Society of Myocardial Infarction
Source : https://pubmed.ncbi.nlm.nih.gov/38147840/
The Guidelines of the 2019 European Society of Cardiology (ESC) and the 5th Society of Lipid and Atherosclerosis (KSoLA) for the Management of Dyslipidemia advocate a more intensive lipid-lowering strategy....
A substantial disparity exists between lipid management guidelines and current clinical practices, highlighting the necessity for clinical research that specifically targets East Asians and Koreans to bridge this gap.
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Glycemic Variability and Time in Range Are Associated With the Risk of Overweight and High LDL-Cholesterol in Children and Youths With Type 1 Diabetes
Source : https://pubmed.ncbi.nlm.nih.gov/38104553/
CGM metrics of glycaemic control and variability were significantly associated with the risk of overweight in females and high LDL-c in both sexes.
Continuous glucose monitoring metrics of glycemic control and variability were significantly associated with the risk of overweight in girls and high LDL-C in both sexes.
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Genetic Insights Into the Association of Statin and Newer Nonstatin Drug Target Genes With Human Longevity: a Mendelian Randomization Analysis
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-023-01983-0
It remains controversial whether the long-term use of statins or newer nonstatin drugs has a positive effect on human longevity. Therefore, this study aimed to investigate the genetic associations between...
Lipid-related gene targets, such as PCSK9, CETP, and APOC3, might potentially regulate human lifespan, thus offering promising prospects for developing newer nonstatin therapies.
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Measuring Lipoprotein(a) for Cardiovascular Disease Prevention - In Whom and When?
Many international guidelines now recommend once in a lifetime measurement of lipoprotein(a) in all adult individuals to facilitate accurate risk prediction. Lipoprotein(a)-lowering therapy to reduce cardiovascular disease is on the...
Many international guidelines now recommend once in a lifetime measurement of lipoprotein(a) in all adult individuals to facilitate accurate risk prediction. Lipoprotein(a)-lowering therapy to reduce cardiovascular disease is on the horizon, with results from the first phase 3 trial expected in 2025.
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