PCSK9 inhibitors for acute coronary syndrome: the era of early implementation
Source : https://www.frontiersin.org/articles/10.3389/fcvm.2023.1138787/full
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, a new cholesterol-lowering strategy, can decrease low-density lipoprotein cholesterol (LDL-C) levels by inhibiting PCSK9 and reducing the degradation of LDL receptors; thus, they...
Conclusion: The current evidence has demonstrated the benefits of early PCSK9 inhibitors in lipid reduction, plaque stabilization, and short-term or long-term cardiovascular event prevention. Furthermore, most adverse effects resulting from early PCSK9 inhibitors are mild and manageable, consistent with long-term follow-up results. However,...
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PCSK9 Inhibition in Patients After Heart Transplantation: a Retrospective Review and Literature Analysis - Current Heart Failure Reports
Source : https://link.springer.com/article/10.1007/s11897-023-00604-2
Purpose of Review Following cardiac transplantation, patients have an increased risk of developing cardiac allograft vasculopathy and atherosclerotic cardiovascular disease. Therefore, aggressive lipid management is indicated. Some patients do not...
Summary: In our study, the 110 patients from literature review were added to a cohort of 7 similar patients from our institution for combined analysis. This report supports that PCSK9 inhibitors should be considered following cardiac transplantation when conventional medial therapy is not tolerated or ineffective.
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![Discovery of [5,5'-bibenzo[d][1,3]dioxol]-6-substituted amine derivatives as potent proprotein convertase subtilisin/kexin type 9 inhibitors - PubMed](https://static-content-prd.skipta.com/public/skipta/skipta-post/2023-05/pubmed-meta-image_207.png "Discovery of [5,5'-bibenzo[d][1,3]dioxol]-6-substituted amine derivatives as potent proprotein convertase subtilisin/kexin type 9 inhibitors - PubMed")
Discovery of [5,5'-bibenzo[d][1,3]dioxol]-6-substituted amine derivatives as potent proprotein convertase subtilisin/kexin type 9 inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37170061/
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target for the treatment of hyperlipidemia. In discovery of novel small molecules that interfere PCSK9/LDLR protein-protein interaction (PPI),...
Conclusions/Relevance: It is significant that molecules D28 and D29 exhibited potential for the treatment of hyperlipidemia in current in vitro investigations. Generally, lead compounds with novel structures were developed in the present study for further design of lipid-lowering molecules by targeting PCSK9/LDLR PPI.
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Inclisiran, Low-Density Lipoprotein Cholesterol and Lipoprotein (a) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37111334/
Dyslipidemia treatment is of major importance in reducing the risk of atherosclerotic cardiovascular disease (ASCVD), which is still the most common cause of death worldwide. During the last decade, a...
Conclusions: Inclisiran exerts a prolonged and significant LDL-C-lowering effect based on its unique mechanism of action. Some of the ORION trials have been completed confirming that inclisiran effectively reduced LDL-C in patients with elevated LDL-C, despite maximally tolerated statin therapy (±ezetimibe), in different clinical...
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Conclusions: HCRU within the first year of ASCVD diagnosis is substantial among patients with ASCVD and elevated Lp(a). Relatively higher rates of inpatient hospitalizations, increased LOS per hospitalization, and requirement of revascularization procedures within the first year of ASCVD index diagnosis were observed in patients with...
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