Hypocholesterolaemic treatment in coronary unit: from statins to anti PCSK9 therapies and bempedoic acid
Source : https://academic.oup.com/eurheartjsupp/article/25/Supplement_B/B55/7135794?login=false
Coronary artery disease remains a major cause of death in the developed world, although many improvements in its prevention and management. Acute coronary syndrome (ACS) [which includes unstable angina, non-ST-segment-elevation...
Conclusions: The benefit of intensive LDL-C lowering to reduce cardiovascular risk is recognized in international guidelines in patients after an ACS. Indeed, ∼20% of ACS survivors experience a subsequent ischaemic cardiovascular event within 24 months and 5-year mortality ranges from 19% to 22%. The risk reduction management of patients...
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Highlights of Cardiovascular Disease Prevention Studies Presented at the 2023 American College of Cardiology Conference - Current Atherosclerosis Reports
Source : https://link.springer.com/article/10.1007/s11883-023-01103-4
Purpose of Review To summarize selected late-breaking science on cardiovascular (CV) disease prevention presented at the 2023 American College of Cardiology (ACC) conference. Recent findings The CLEAR outcomes randomized control...
Summary: The late-breaking clinical science presented at the 2023 conference of the ACC paves the way for an evidence-based alternative to statin therapy and provides data on several common clinical scenarios encountered in daily practice.
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Lipoprotein(a) concentrations in acute myocardial infarction patients are not indicative of levels at six month follow-up
Source : https://academic.oup.com/ehjopen/article/3/2/oead035/7107070?login=false
Lipoprotein(a) [Lp(a)] is a low-density lipoprotein like particle containing apolipoprotein B covalently linked to a carbohydrate-rich protein termed apolipoprotein(a) [apo(a)]. Mechanistic and epidemiologic studies indicate that Lp(a) levels are significantly...
Conclusion: This study demonstrated that Lp(a) levels in individuals with acute MI are significantly higher six months after the initial event. Therefore, a single measurement of Lp(a) in the peri-infarction setting is not sufficient to predict the Lp(a)-associated CAD risk in the post-infarction period.
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Conclusions and relevance: In this cohort study of Asian patients with breast cancer, statin use was associated with a reduced risk of cancer-associated death rather than cardiovascular death. Our findings provide evidence to support the use of statins in patients with breast cancer; however, randomized studies are necessary.
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Familial Hypercholesterolemia: Challenges for a High-Risk Population: JACC Focus Seminar 1/3
Source : https://www.sciencedirect.com/science/article/abs/pii/S0735109723045229?via=ihub
The availability of , , and (FH). However, a great number of individuals with FH do not achieve guideline-recommended low-density lipoprotein (LDL) cholesterol levels despite maximal lipid-lowering therapy. Novel therapies...
Conclusions/Relevance: Conduction of cardiovascular outcomes clinical trials in patients with FH can be challenging because of difficulty in recruitment and long periods of follow-up. In the future, the use of validated surrogate measures of atherosclerosis may allow for clinical trials with fewer study participants and shorter duration,...
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