Long-term cancer risk in heterozygous familial hypercholesterolemia relatives: a 25-year cohort study - Lipids in Health and Disease
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-022-01666-2
Background Heterozygous familial hypercholesterolemia (HeFH) due to low-density lipoprotein receptor (LDLR) mutations predisposes patients to highly elevated levels of cholesterol, and patients are at increased risk of adverse cardiovascular events...
Conclusion: In Denmark, LDLR mutation-carrying HeFH relatives did not have a different cancer risk than the general population. In contrast, nonmutation-carrying relatives had a lower risk of cancer.
-
Amy Gonzales, Physician4yrInteresting study and kudos to the researchers for being able to follow-up patients long-term. Will need more studies and probably see if also applicable in other countries. This study also Show More -
Lipid Management Connect4yrKey Takeaways • Source: Lipids in Health and Disease • Conclusion: “In Denmark, LDLR mutation-carrying HeFH relatives did not have a different cancer risk than the general population. In contrast, nonmutation-carrying relatives had a Show More
Comparative study on the performance of different classification algorithms, combined with pre- and post-processing techniques to handle imbalanced data, in the diagnosis of adult patients with familial hypercholesterolemia
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269713
Familial Hypercholesterolemia (FH) is an inherited disorder of cholesterol metabolism. Current criteria for FH diagnosis, like Simon Broome (SB) criteria, lead to high false positive rates. The aim of this...
Relevance: Familial Hypercholesterolemia (FH) is an inherited disorder of cholesterol metabolism. Current criteria for FH diagnosis, like Simon Broome (SB) criteria, lead to high false positive rates. The aim of this work was to explore alternative classification procedures for FH diagnosis, based on different biological and biochemical...
-
Dr Hamid4yrFH diagnosis, based on different biological and biochemical indicators
Modifiable potential risk factors in familial and sporadic frontotemporal dementia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35767471/
doi: 10.1002/acn3.51619. Online ahead of print. 1 Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland. 2 Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences,...
Interpretation: Our study suggests distinct profiles of several modifiable factors in the FTD group depending on the phenotype and familial inheritance history and that especially sporadic FTD may be associated with modifiable risk factors.
Childhood beverage intake and risk of hypertension and hyperlipidaemia in young adults
Source : https://www.tandfonline.com/doi/abs/10.1080/09637486.2022.2091524?journalCode=iijf20
Abstract An epidemiological analysis assessing beverage consumption and risk factors for cardiovascular disease was conducted. Participants were 9-16 years old at enrolment, completed food frequency questionnaires in 1996-2001 and self-reported outcomes...
Conclusion: This study can guide beverage consumption as it relates to early predictors of cardiovascular disease.
Time-averaged low-density lipoprotein cholesterol lowering with evolocumab: Pooled analysis of phase 2 trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35760720/
LDL-C is the pivotal risk factor for atherosclerotic cardiovascular disease, and the benefit from LDL-C lowering is proportional to the magnitude of reduction. Clinical trials demonstrate that evolocumab reduces LDL-C...
Conclusion: The time-averaged measure yielded LDL-C reductions for evolocumab that exceeded measurements at the end of dosing intervals and may provide a better estimate of cardiovascular benefit during long-term therapy.