Acute Effect of Evolocumab on Lipoprotein(a) Level and Inflammation in Patients with Coronary Artery Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35448076/
doi: 10.3390/jcdd9040101. 1 Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul 02447, Korea. 2 Department of Medicine, Graduate School of Medicine, Kyung Hee...
Conclusions: One-time PCSK9 inhibitor treatment may be effective in lowering Lp(a) levels in Korean patients in the short term.
PCSK9 inhibition protects against myocardial ischemia-reperfusion injury via suppressing autophagy
Source : https://www.sciencedirect.com/science/article/abs/pii/S0026286222000619?via=ihub
the expression levels of PCSK9 and autophagy markers rose in a proportional ratio with increasing reperfusion time, peaking at 1 day of reperfusion and thereafter decreased. Meanwhile, we believe that...
Conclusion/Relevance: These results suggest that combined treatment with rosuvastatin (but not lovastatin or ezetimibe) and evolocumab can control LDL-C to meet the LDL-C treatment goal for patients with LDLR splicing mutation c.1187-2A>G.
Does eating eggs matter? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35420270/
Dietary cholesterol is absorbed in proportion to the amount ingested, blocking its hepatic synthesis, increasing its biliary excretion, only slightly increasing production of bile acids while potentially raising the serum...
Conclusion/Relevance: A practical useful suggestion is to measure for a few weeks the total serum cholesterol and its fractions at least three times before and during the intake of eggs that the candidate wishes to maintain in his usual dietary practice as an efficient procedure to identify those who respond with undesirable increases in serum...
No association between APOE genotype and lipid lowering with cognitive function in a randomized controlled trial of evolocumab - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35404972/
APOE encodes a cholesterol transporter, and the ε4 allele is associated with higher circulating cholesterol levels, ß-amyloid burden, and risk of Alzheimer's disease. Prior studies demonstrated no significant differences in...
Conclusion/Relevance: In the subset of participants who underwent objective cognitive testing with the CANTAB, APOE genotype did not significantly modify the relationship between treatment arm and CANTAB performance after adjustment for demographic and medical covariates, (p's>.05). Although analyses were limited by the low population...
Atherosclerotic Cardiovascular Disease Risk and Lipid-Lowering Therapy Requirement in China
Source : https://www.frontiersin.org/articles/10.3389/fcvm.2022.839571/full
BackgroundLipid-lowering therapy (LLT) is one of the key strategies for reducing the atherosclerotic cardiovascular disease (ASCVD) burden. However, little is known about the percentage of people in need of different...
Conclusions: Moderate-intensity statin therapy is pivotal for the attainment of optimal LDL-C goals in China, and around 10–25% of high- or very-high-risk patients would require additional non-statin agents. There is an opportunity to reduce the rising ASCVD burden in China by optimizing LLT.