Drug Treatment of Hypercholesterolemia in Older Adults: Focus on Newer Agents - Drugs & Aging
Source : https://link.springer.com/article/10.1007/s40266-022-00928-z
There is increasing research interest in cholesterol-lowering therapy in older patients. The newer lipid-lowering agents (the proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitors evolocumab and alirocumab; the PCSK9 synthesis inhibitor...
Conclusions: The newer lipid-lowering agents could be added to other lipid-lowering medication or used as an alternative treatment in older patients with documented statin intolerance (as is already recommended in guidelines for the PCSK9 inhibitors), such as myopathy. Especially in older patients needing high-intensity therapy despite...
Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35276884/
This study aimed to determine how the microbiota profile might be predisposed to a better response in blood lipid profiles due to dietary fibre supplementation. A three-arm intervention study that...
Conclusion: It was concluded that the non-responsiveness to dietary fibre treatment might be mediated by the lack of ability to maintain a stable SCFA producing bacteria diversity and composition after extra fibre intake.
Beneficial Effects of Spirulina Consumption on Brain Health - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35277035/
Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies. It is extensively utilized as a nutraceutical food supplement all over the world due to its high levels...
Conclusion/Relevance: This review focuses on the role of Spirulina in the brain, highlighting how it exerts its beneficial anti-inflammatory and antioxidant effects, acting on glial cell activation, and in the prevention and/or progression of neurodegenerative diseases, in particular Parkinson's disease, Alzheimer's disease and Multiple...
Clinical and genetic features of sitosterolemia in Japan
Source : https://www.sciencedirect.com/science/article/abs/pii/S0009898122000808?via=ihub
We are providing clinical and genetic features of Japanese patients with sitosterolemia. * A particular missense mutation in ABCG5 accounts for 24 % of pathogenic mutation. * There are 3...
Conclusion/Relevance: We are providing a demographic overview of the clinical and genetic backgrounds of Japanese patients with sitosterolemia.
Comparative efficacy of non-statin lipid-lowering therapies in patients with hypercholesterolemia at increased cardiovascular risk: a network meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35262430/
This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful...
Conclusions: This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful improvements in low-density lipoprotein cholesterol in patients with hypercholesterolemia on maximally...