Approaches to Visualising Endocytosis of LDL-Related Lipoproteins - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35204658/
Endocytosis is the process by which molecules are actively transported into cells. It can take on a variety of forms depending on the cellular machinery involved ranging from specific receptor-mediated...
Conclusion/Relevance: The aim of this review is to outline the many endocytic pathways utilised for lipoprotein uptake. It explores the various experimental approaches that have been applied to visualise lipoprotein endocytosis with an emphasis on LDL and its more complex counterpart, lipoprotein(a) [Lp(a)]. Finally, we look at new...
Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review
Source : https://www.sciencedirect.com/science/article/abs/pii/S0735109721084448?via=ihub
Addressing risk factors in individuals aged 20-39 years can reduce premature atherosclerotic cardiovascular disease. * Tobacco cessation and managing hypertension, hypercholesterolemia, diabetes, sex-specific risk factors, and metabolic syndrome are essential....
Relevance: The authors update current thinking on lipid risk factors such as triglycerides, non–high-density lipoprotein cholesterol, apolipoprotein B, or lipoprotein (a) that are useful in understanding an individual’s long-term ASCVD risk. The authors review emerging strategies, such as coronary artery calcium and polygenic risk scores...
Pharmacological treatment with lipid-lowering agents after molecular identification of familial hypercholesterolemia: results from the Hipercol Brasil cohort - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35181259/
Index cases with a positive genetic result increase their prevalence of lipid-lowering medication use. Positive relatives did not have the expected adherence; we could notice a significant increase in the...
Conclusion: Index cases with a positive genetic result increase their prevalence of lipid-lowering medication use. Positive relatives did not have the expected adherence; we could notice a significant increase in the prevalence of treatment starting after a positive genetic test. The independent predictors for lipid-lowering treatment were...
Clinical decision support for familial hypercholesterolemia (CDS-FH): Rationale and design of a cluster randomized trial in primary care
Source : https://www.sciencedirect.com/science/article/pii/S000287032200031X?via=ihub
Familial hypercholesterolemia (FH) is an underdiagnosed and undertreated genetic disorder with high risk of premature atherosclerotic cardiovascular disease and death. Clinical decision support (CDS) systems have the potential to aid...
Conclusion: Despite increasing awareness of FH, the condition remains underdiagnosed and undertreated. The present study will investigate whether a CDS can increase the number of patients being diagnosed with FH.
Low density lipoprotein cholesterol levels exceed the recommended European threshold for PCSK9i initiation: lessons from the HEYMANS study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35175350/
Across Europe, LDL-C levels at evolocumab initiation were three times higher than recommended thresholds for PCSK9i initiation, reflecting disparities between implementation and guidelines. More patients attained risk-based LDL-C goals when...
Conclusions: Across Europe, LDL-C levels at evolocumab initiation were three times higher than recommended thresholds for PCSK9i initiation, reflecting disparities between implementation and guidelines. More patients attained risk-based LDL-C goals when receiving evolocumab in combination with LLT versus those not receiving combination...