Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction - BMC Cardiovascular Disorders
Source : https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-021-02383-x
Background Data on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited. The present study is to evaluate whether elevated SUA predicts the development of LDL-C in the first AMI.
Conclusion: "Among Chinese patients with first AMI, higher baseline SUA was associated with higher LDL-C deduction percentage (%), and higher rate of LDL-C control in the short-term follow-up, respectively. SUA acquired when AMI occurred was prone to be profitable in predicting the risk stratification of uncontrolled LDL-C and dyslipidemia management."
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• Source: BMC Cardiovascular Disorders
• Conclusions: “Among Chinese patients with first AMI, higher baseline SUA was associated with higher LDL-C deduction percentage (%), and higher rate of LDL-C control in the short-term follow-up, respectively. SUA acquired when AMI occurred was prone to be profitable in predicting the risk stratification of uncontrolled LDL-C and dyslipidemia management.”
• In the current 6-month retrospective cohort study, researchers sought to determine whether elevated serum uric acid (SUA) predicted the development of LDL-C in 465 hospitalized, Chinese patients experiencing a first acute myocardial infarction (AMI).
• After adjusting for covariates, a single-SD increment in change of baseline SUA (i.e., μmol/L) was related to a 3.96% decrease of LDL-C.
• Underlying mechanisms remain to be elucidated but could be due to the association between higher SUA and unhealthy lifestyles such as a diet rich in UAs. Another cause could be enzymatic reactions between SUA and LDL-C levels.
• A strength of this study is that it’s the first to analyze the predictive value of baseline SUA with regard to changes in LDL-C levels in AMI patients. Limitations include its single-center, retrospective nature. Second, the patients were on different dosages of diuretics and statin, which could impact lipid levels. Finally, the population was ethnically southern Chinese, which could impact generalizability to other populations.