Nationwide Trends in Dispensing of Sodium Glucose Cotransporter 2 Inhibitors
Source : https://www.cjhp-online.ca/index.php/cjhp/article/view/3066
Michael Fralick Sinai Health System, University of Toronto Diana Martins Unity Health Toronto Mina Tadrous Women's College Research Institute, Women's College Hospital; ICES; University of Toronto Tara Gomes Unity Health...
Conclusions: The cardiovascular outcome trials appeared to have an important impact on the dispensing of SGLT2 inhibitors in Canada.
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Twenty-Four Hour Blood Pressure Response to Empagliflozin and Its Determinants in Normotensive Non-diabetic Subjects - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35391843/
doi: 10.3389/fcvm.2022.854230. 1 Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. 2 Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital,...
Conclusion: SGLT2 inhibition lowers daytime and nighttime ambulatory systolic and diastolic BP in normotensive non-diabetic subjects. Twenty-four jour changes are pronounced and comparable to those described in diabetic or hypertensive subjects. Baseline ambulatory BP was the only identified determinant of systolic and diastolic BP response....
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Cardiovascular benefits of empagliflozin are associated with gut microbiota and plasma metabolites in type 2 diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35397165/
doi: 10.1210/clinem/dgac210. Online ahead of print. 1 Department of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou,...
Conclusions: Empagliflozin may be a superior initial therapy for patients with T2DM at risk of CVDs; its cardiovascular benefits may be associated with shifts in gut microbiota and plasma metabolites.
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SGLT2 Inhibitors in Type 2 Diabetes Mellitus and Heart Failure-A Concise Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35329796/
The incidence of both diabetes mellitus type 2 and heart failure is rapidly growing, and the diseases often coexist. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are a new antidiabetic drug class...
Conclusions: The expected paradigm shift in treatment strategies was reflected in the most recent 2021 guidelines published by the European Society of Cardiology, recommending dapagliflozin and empagliflozin as first-line treatment for heart failure patients with reduced ejection fraction. Moreover, the recent results of the EMPEROR-Preserved...
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Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy-effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker - BMC Nephrology
Source : https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-022-02747-1
Background Host factors such as angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease, serine-subtype-2 (TMPRSS2) are important factors for SARS-CoV-2 infection. Clinical and pre-clinical studies demonstrated that RAAS-blocking agents can...
Conclusions: Our study indicated that there is no upregulation regarding host factors potentially promoting SARS-CoV-2 virus entry into host cells when the SGLT2-blocker empagliflozin, telmisartan and the DPP4-inhibitor blocker linagliptin are used. The results obtained in a preclinical, experimental non-diabetic kidney failure model need...
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