Branched-Chain Amino Acid Metabolism in the Failing Heart - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35150384/
Branched-chain amino acids (BCAAs) are essential amino acids which have critical roles in protein synthesis and energy metabolism in the body. In the heart, there is a strong correlation between...
Conclusion: Dietary and pharmacological interventions that enhance cardiac BCAA oxidation and limit the accumulation of cardiac BCAAs and BCKAs have been shown to have cardioprotective effects in the setting of ischemic heart disease and heart failure. Thus, targeting cardiac BCAA oxidation may be a promising therapeutic approach for heart...
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New therapeutic options for patients with heart failure with reduced ejection fraction and acute decompensated heart failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35101654/
Peri-discharge initiation of treatment with new molecules is possible and safe for patients with HFrEF and ADHF. New molecules, if administered before discharge or shortly after, reduce the risk of...
Conclusions: Peri-discharge initiation of treatment with new molecules is possible and safe for patients with HFrEF and ADHF. New molecules, if administered before discharge or shortly after, reduce the risk of cardiovascular death or worsening heart failure within the vulnerable phase, and are also nephroprotective.
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SGLT2 Inhibitors in Older Adults with Heart Failure with Preserved Ejection Fraction - Drugs & Aging
Source : https://link.springer.com/article/10.1007/s40266-022-00920-7
Heart failure is an important medical condition that is prevalent in older adults. Multiple therapies have been identified that improve clinical outcome in heart failure with a reduced ejection fraction....
Relevance: In this current opinion article, we have therefore provided more information on how to translate the findings of the EMPEROR-Preserved trial to the setting of older adults, with a focus on the impact of empagliflozin on hospitalizations, both heart failure-related and all-cause. To better understand the importance of...
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Egyptian expert opinion for the use of sodium‐glucose cotransporter‐2 inhibitors in patients with heart failure with reduced ejection fraction
Source : https://onlinelibrary.wiley.com/doi/10.1002/ehf2.13811
Magdy Abdelhamid , Corresponding Author Magdy Abdelhamid Faculty of Medicine, Kasr Al Ainy, Cardiology Department, Cairo University, Cairo, Egypt Correspondence to: Magdy Abdelhamid, Faculty of Medicine, Kasr Al Ainy, Cardiology...
Relevance: Considering the magnitude of the problem and the expected benefit on the target population, an Egyptian consensus document was conducted to demonstrate the importance of and the critical knowledge needed for effective and safe implementation of SGLT2i in the daily practice for the management of patients with HFrEF.
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Empagliflozin improves quality of life in nondiabetic HFrEF patients. Sub-analysis of the EMPATROPISM trial
Source : https://www.sciencedirect.com/science/article/abs/pii/S1871402122000315?via=ihub
Empagliflozin proves benefit on health status in the non-diabetic, ethnic minority represented, EMPATROPISM trial population. * A significant mean improvement of 22 points in Kansas City Cardiomyopathy Questionnaire (KCCQ) was...
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Conclusions: Empagliflozin benefits quality of life in the non-diabetic, ethnic minority represented, EMPATROPISM trial population.
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