Impact of concomitant mitral valve surgery on the clinical outcomes of patients with moderate functional mitral regurgitation and HFpEF undergoing aortic valve replacement: a cohort study - Journal of Cardiothoracic Surgery
Source : https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-023-02197-2
Background Functional mitral regurgitation (FMR) worsens the prognosis of patients with heart failure with preserved ejection fraction (HFpEF). While concomitant mitral valve surgery (MVS) is recommended for severe FMR during...
Conclusion: In patients with moderate FMR and HFpEF, isolated AVR might be more reasonable than AVR-MVS.
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Pushing the Limits of Medical Management in HCM: A Review of Current Pharmacological Therapy Options - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34281272/
Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiac disease with a highly variable phenotypic expression, ranging from asymptomatic to drug refractory heart failure (HF) presentation. Pharmacological therapy is the...
Relevance: With new data gathering these past years as well as the development of a new drug class showing promising results, this review provides an up-to-date focused synthesis of existing medical treatment options and future directions for HCM pharmacological treatment.
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Sodium-glucose cotransporter-2 inhibitors and cardiovascular clinical outcomes in acute heart failure: A narrative review
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Conclusion: SGLT2 inhibitors may have a role in inpatient management of acute HF, provided there is close monitoring for fluctuations in hemodynamic, fluid, and electrolyte status. Initiation of SGLT2 inhibitors at the time of acute HF may promote optimized GDMT, continued medication adherence, and reduced risk of CV outcomes.
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Health Status Across Major Subgroup of Patients with Heart Failure and Preserved Ejection Fraction - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36974746/
Health status in patients with HFpEF is impaired, especially in elderly, women, and those with obesity and comorbidities. Empagliflozin improved health status among all key subgroups studied with a greater...
Conclusion: Health status in patients with HFpEF is impaired, especially in elderly, women, and those with obesity and comorbidities. Empagliflozin improved health status among all key subgroups studied with a greater effect in obese patients.
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Systematic review of sodium-glucose cotransporter 2 inhibitors: a hopeful prospect in tackling heart failure-related events - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36967133/
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Discussion: The RCTs investigating the effects of the SGLT2 inhibitors found robust results on significant reductions in three-point MACE (MACE-3), HHF, as well as renal function in patients with HF across the range of phenotypes according to LVEF (HFrEF, HFmrEF, and HFpEF). Additionally, a meta-analytic effect of AF as one of the adverse...
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