Angiotensin pathways under therapy with empagliflozin in patients with chronic heart failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36782339/
Our data indicate that empagliflozin might lead to an activation of both the Ang I-ACE-Ang II receptor axis and the Mas-axis pathway. Activation of the Ang I-ACE-Ang II receptor axis...
Conclusions: Our data indicate that empagliflozin might lead to an activation of both the Ang I-ACE-Ang II receptor axis and the Mas-axis pathway. Activation of the Ang I-ACE-Ang II receptor axis and the protective Mas-axis pathway after initiating treatment with empagliflozin was only seen in patients with ARB co-medication, in contrast to...
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Heart Failure Connect3yrKey Points • Source: ESC Heart Failure • Conclusions/Relevance: “Our data indicate that empagliflozin might lead to an activation of both the Ang I–ACE–Ang II receptor axis and the Mas-axis pathway. Activation of the Show More
Acute Biomechanical Effects of Empagliflozin on Living Isolated Human Heart Failure Myocardium - Cardiovascular Drugs and Therapy
Source : https://link.springer.com/article/10.1007/s10557-023-07434-3
Purpose Multiple randomized controlled trials have presented SGLT2 inhibitors (SGLT2i) as novel pharmacological therapy for patients with heart failure, resulting in reductions in hospitalization for heart failure and mortality. Given...
Conclusion: The addition of empagliflozin to LMS from end-stage heart failure patients cultured in a biomimetic system improves contraction and relaxation kinetics by increasing total contraction duration without diminishing maximum force production. Therefore, we present convincing evidence that SGLT2i can directly act on the myocardium in...
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Oral empagliflozin-loaded tri-layer core-sheath fibers fabricated using tri-axial electrospinning: Enhanced in vitro and in vivo antidiabetic performance
Source : https://www.sciencedirect.com/science/article/abs/pii/S0378517323001369?via=ihub
Empagliflozin-loaded PCL/PLA/PMMA nanofibers (EMF) were produced by tri-axial ES. * The expression of glucokinase and GLUT-2 was increased by EMF in the rat β-cell line. * The bioavailability was improved...
Relevance: EMF is suggested as an unprecedented and promotive treatment approach for T2DM with a higher bioavailability and better antidiabetic effect compared to conventional dosage forms.
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Empagliflozin and renal sodium-hydrogen exchange in healthy subjects
Source : https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgad088/7041118?login=false
AbstractContext. Sodium glucose co-transporter-2 inhibitors (SGLT2i) exert clinically relevant cardiorenal protection. Among several mechanisms, inhibition of t
Conclusions: In healthy young volunteers, empagliflozin acutely increases urinary pH while inducing a substrate shift towards lipid utilization and ketogenesis, without significant changes in renal NHE3 protein expression.
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Combining Three Independent Pathological Stressors Induces a Heart Failure with Preserved Ejection Fraction Phenotype - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36763506/
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Conclusions: The 3-Hit mouse model induced a reliable HFpEF phenotype with CM hypertrophy, cardiac fibrosis, and increased M2 macrophage population. This model could be used for identifying and preclinical testing of novel therapeutic strategies.
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