Empagliflozin Ameliorates Diabetic Cardiomyopathy via Attenuating Oxidative Stress and Improving Mitochondrial Function - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35585884/
Diabetic cardiomyopathy (DCM) is considered to be a critical contributor to the development of heart failure. Empagliflozin (EMPA), a sodium-glucose cotransporter 2 inhibitor, has been shown to prevent cardiovascular events...
Relevance: Diabetic cardiomyopathy (DCM) is considered to be a critical contributor to the development of heart failure. Empagliflozin (EMPA), a sodium-glucose cotransporter 2 inhibitor, has been shown to prevent cardiovascular events and reduce the incidence of heart failure in randomized clinical trials. However, the mechanism of how EMPA...
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Comparison of cardiovascular outcomes between SGLT2 inhibitors in diabetes mellitus - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35585590/
The risks for subsequent development of HF, MI, AP, stroke, and AF were comparable between individual SGLT2 inhibitors. This is the first study comparing the wide-range cardiovascular outcomes of patients...
Conclusion: The risks for subsequent development of HF, MI, AP, stroke, and AF were comparable between individual SGLT2 inhibitors. This is the first study comparing the wide-range cardiovascular outcomes of patients with DM treated with individual SGLT2 inhibitors using large-scale real-world data.
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Metabolomics study reveals the alteration of fatty acid oxidation in the hearts of diabetic mice by empagliflozin
Source : https://pubs.rsc.org/en/content/articlelanding/2022/MO/D2MO00036A
Empagliflozin (Empa, SGLT2 inhibitor) is widely used in clinical situations for the management of diabetes. It has beneficial effects in reducing cardiac dysfunction and heart failure. However, rare studies have...
Conclusion: These results suggest that fatty acid oxidation is one of the targets for Empa treatment in the heart of db/db mice. This study provided new possibilities for the development of therapeutic interventions for diabetic cardiomyopathy.
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Successful use of empagliflozin to treat neutropenia in two G6PC3-deficient children: Impact of a mutation in SGLT5 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35506446/
doi: 10.1002/jimd.12509. Online ahead of print. 1 Biologie Hématologique, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium. 2 Service de Gastro-Entérologie et Hépatologie Pédiatrique, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium. 3 Groupe...
Conclusion: Our data shows that SGLT2 inhibitors are an excellent alternative to treat the neutropenia present in G6PC3-deficiency
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Management strategies in heart failure with preserved ejection fraction
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075717/
Language: English | German The diagnosis and therapy of heart failure with preserved ejection fraction (HFpEF) remain challenging. Currently, there are ongoing discussions on whether the diagnosis of HFpEF should...
Conclusion: Overall, this review aims to enhance the knowledge on the diagnostic processes and best treatments available for HFpEF patients.
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